Browsing CHEM Faculty Scholarship by Type "Abstract"
Now showing items 1-20 of 33
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2-APB and CGP-37157 as neuroprotective agents against the toxicity and uptake of 1-methyl-4-phenylpyridinium in dopaminergic MN9D cell
(American Chemical Society, 2017)Parkinson's disease (PD) is characterized by the death of dopaminergic neurons in the substania nigra, a region in the midbrain. The cause of this dopaminergic cell death is unknown and current therapies have not been ... -
Analysis of enzyme and solvent dynamics of Candida antarctica lipase B in non-aqueous solvents using molecular dynamics simulations
(American Chemical Society, 2014-08-10)Solvents play a major role in changing biomolecule structure, dynamics and functions. The main objective of this project is to use molecular dynamics simulations to shed light on enzyme-solvent interactions between Candida ... -
Application of photoexcited states of Re (I) metal complexes to solar energy conversion
(American Chemical Society, 2014-03-16)Dye sensitized solar cells (Grätzel Cell) have attracted significant attention as promising next generation photovoltaic devices. In a photovoltaic cell, the dye sensitizers anchored to mesoporous thin films made of the ... -
Carbon nanomaterials for new generation solar cells
(American Chemical Society, 2018)Recently, we invented various types of 3D carbon nanomaterials via invented reactions. Those novel materials possess high elec. cond. and large accessible surface area, which are required for ideal electrode materials. ... -
Characterizing dynamical differences between TEM-1 and TEM-52 beta-lactamases
(Cell Press, 2019-02-15)Beta-lactamase, produced in bacteria, defends against beta-lactam antibiotics such as penicillin and cephalosporins by hydrolyzing the beta-lactam ring. This is a primary cause of antibiotic resistance to beta-lactam ... -
Conformational Changes in Palladin Actin-Binding Domains Measured by Fluorescent Resonance Energy Transfer
(Federation of American Societies for Experimental Biology, 2017-04)The fundamental goal of our research is to understand how cell motility in both normal and metastatic cells is regulated by palladin, an actin binding protein that plays a key role in remodeling the actin cytoskeleton. Our ... -
Conformational dynamics of E. coli YqhD oxidoreductase in the presence of substrates
(American Chemical Society, 2014-08-10)E. coli YqhD exhibits aldehyde reductase and alcohol dehydrogenase activity with a broad substrate range. It has applications in the production of valuable biorenewable fuels and chemicals, such as isobutanol and ... -
Controlling the role of oxygen in single molecule fluorescence measurements
(American Chemical Society, 2011-08-28) -
Derivatized mixed-ring heterocyclic and antenna carotene ligands
(American Chemical Society, 2018)General synthetic methods have been devised to prep. derivatized mixed-ring heterocyclic and antenna carotene ligands with nitrogen donor atoms. Synthetic methods involve prepn. of intermediate compds. in route to arom. ... -
Digital data usage in the chemistry classroom and laboratory
(American Chemical Society, 2014-08-10)It is important for science students to understand the basic concepts of statistical analysis and both linear regression and non-linear regression analysis of digital experimental data. Excel spreadsheets are often used ... -
Dye sensitized solar photoelectrochemical cells
(American Chemical Society, 2013-09-08)The use of dye sensitized solar photoelectrochemical cells offers an alternative source of energy using visible light from the sun. A typical cell contains a photoanode, a platinum cathode and the I3-/I- electrolyte. The ... -
Electronic structure calculations of fluorohistidine isomers
(American Chemical Society, 2014-08-10)This work assesses the stability and NMR shifts of fluorinated amino acids in different solvents. We have considered the τ and π tautomers for both 2-fluorohistidine (2F-his) and 4-fluorohistidine (4F-his) corresponding ... -
Evolution of stability/flexibility relationships in beta-lactamase
(Cell Press, 2019-02-15)We have curated over 100 structures of class A beta-lactamase proteins, a family of enzymes that is responsible for a considerable percentage of multidrug antibiotic resistance in bacteria. Our dataset includes three ... -
Fenamate protects against 1-methyl-4-phenylpyridinium-induced apoptosis in dopaminergic MN9D cells
(American Chemical Society, 2018)Parkinson's disease (PD) is a neurodegenerative disease caused by the death of dopaminergic neurons in substania nigra. While the causes of PD under mol. level have not been fully identified, it is necessary to identify ... -
Improving personalized medicine by examining structure-function patterns in the non-conserved regions of lactate dehydrogenase (LDH)
(Federation of American Societies for Experimental Biology, 2017-04)Personalized medicine relies on our ability to make predictions about disease susceptibility based on differences in protein or gene sequences. Recent research has suggested that the non-conserved regions of proteins, those ... -
Insight into Ligand Binding and Conformational Dynamics of Kynurenine 3-Monooxygenase
(Cell Press, 2018-02-02)Cellular and developmental pathogenesis is the result of complicated cellular processes involving molecular interactions among cells and their intra- and inter-cellular milieus. The characterization of molecular interactions ... -
Insight into the broad substrate promiscuity of E. coli alcohol dehydrogenase
(American Chemical Society, 2014-03-20)The NADPH-dependent alcohol dehydrogenase (YqhD) from E. coli is a promiscuous enzyme with low substrate specificity. YqhD exhibits aldehyde reductase and alcohol dehydrogenase activity with a broad substrate range and ... -
Investigating photoinduced energy and electron transfer mechanisms in ferrocene-zinc porphyrin-boron dipyrrin-fullerene supramolecular construct
(American Chemical Society, 2014-03-16)Photoinduced energy (EnT) and electron transfer (ET) processes have been the driving force in the conversion of solar energy to electrical energy or fuels. Understanding the mechanism is vital in designing “antenna-reaction ... -
Myopalladin's role in cardiac muscle function and disease
(Federation of American Societies for Experimental Biology, 2017-04)Decades of research have provided fundamental insight into the human heart’s structure and function. Yet, most cardiac malformations remain a mystery as scientists and clinicians continue to examine how inherited mutations ... -
Palladin and regulation of actin crosslinking and dynamics
(Wiley-Blackwell, 2012-08)Palladin is a recently discovered actin-associated protein that appears to be involved in both normal cell migration and invasive cell motility. Recently, we demonstrated that palladin is able to both bind and bundle actin ...