Browsing CHEM Faculty Scholarship by Title
Now showing items 1-20 of 491
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1,2,5, thiadiazolidin-3-one 1,1-dioxide derivatives
(United States Patent and Trademark Office, 2002-07-16)Substituted derivatives of 1,2,5-thiadiazolidin-3-one 1,1-dioxides, oligomers containing them, and methods of using them. -
1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases
(Elsevier, 2001-01-01)The 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold (I) embodies a motif that allows it to dock to the active site of (chymo)trypsin-like proteases in a predictable and substrate-like fashion. Consequently, inhibitors ... -
1,2,5-Thiadiazolidin-3-one 1,1-dioxide-based heterocyclic sulfides are potent inhibitors of human tryptase
(Elsevier, 2005-04-01)We describe herein the design, synthesis, and in vitro biochemical evaluation of a series of potent, time-dependent inhibitors of the mast cell-derived serine protease tryptase. The inhibitors were readily obtained by ... -
19F nuclear magnetic resonance and crystallographic studies of 5-fluorotryptophan-labeled anthrax protective antigen and effects of the receptor on stability
(American Chemical Society, 2014-02-04)The anthrax protective antigen (PA) is an 83 kDa protein that is one of three protein components of the anthrax toxin, an AB toxin secreted by Bacillus anthracis. PA is capable of undergoing several structural changes, ... -
2, 2'-and 4, 4'-Cyanines are transporter-independent in vitro dopaminergic toxins with the specificity and mechanism of toxicity similar to MPP+
(Wiley Periodicals, Inc., 2015-11)Specific uptake through dopamine transporter followed by the inhibition of the mitochondrial complex-I have been accepted as the cause of the specific dopaminergic toxicity of 1-methyl-4-phenylpyridinium (MPP+). However, ... -
2-APB and CGP-37157 as neuroprotective agents against the toxicity and uptake of 1-methyl-4-phenylpyridinium in dopaminergic MN9D cell
(American Chemical Society, 2017)Parkinson's disease (PD) is characterized by the death of dopaminergic neurons in the substania nigra, a region in the midbrain. The cause of this dopaminergic cell death is unknown and current therapies have not been ... -
2-Fluoro-l-histidine
(International Union of Crystallography, 2010-01-01)The title compound, C(6)H(8)FN(3)O(2), an analog of histidine, shows a reduced side-chain pK(a) (ca 1). The title structure exhibits a shortening of the bond between the proximal ring N atom and the F-substituted ring C ... -
3-(Alkylthio)-N-hydroxysuccinimide derivatives: potent inhibitors of human leukocyte elastase
(Elsevier, 1993-08-07)A series of 3-(alkylthio)-N-hydroxysuccinimide derivatives was synthesized and their inhibitory activity towards human leukocyte elastase (HLE) was investigated. The interaction of the compounds having a 3-alkylthioether ... -
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice
(NLM (Medline), 2020-08-19)Pathogenic coronaviruses are a major threat to global public health, as exemplified by severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the newly emerged ... -
3S-fluoroproline as a probe to monitor proline isomerization during protein folding by 19F-NMR
(Royal Society of Chemistry, 2009-06-21)Variable-temperature inversion transfer NMR is used to determine the kinetic and thermodynamic parameters of cis-trans isomerization of N-Ac-(3R) and (3S)-fluoroproline-OMe. -
A$_2$P$_2$S$_6$ (A = Ba and Pb): a good platform to study the polymorph effect and lone pair effect to form an acentric structure
(The Royal Society of Chemistry, 2022-05-14)Three ternary thiophosphates α-Ba$_2$P$_2$S$_6$, β-Ba$_2$P$_2$S$_6$, and Pb$_2$P$_2$S$_6$ were synthesized via a high temperature salt flux method or an I2 transport reaction. β-Ba$_2$P$_2$S$_6$ and Pb$_2$P$_2$S$_6$ were ... -
Acid monolayer functionalized iron oxide nanoparticles as catalysts for carbohydrate hydrolysis
(Royal Society of Chemistry, 2014-02)Superparamagnetic iron oxide nanoparticles were functionalized with a quasi-monolayer of 11-sulfoundecanoic acid and 10-phosphono-1-decanesulfonic acid ligands to create separable solid acid catalysts. The ligands are bound ... -
Acid-Base and Electrochemical Properties of the MLCT Excited States and One-Electron-Reduced Forms of Ruthenium(II) Complexes Containing 2-(2'-Pyridyl)pyrimidine and 2,2'-Bipyridine in Aqueous Solution
(American Chemical Society, 1997-05-21)The acid-base and electrochemical properties of the MLCT excited states and the one-electron-reduced forms of the three Ru(bpy)(3)(-)()(p)()(pypm)(p)()(2+) complexes, where bpy = 2,2'-bipyridine, pypm = 2-(2'-pyridyl)pyrimidine, ... -
Acid-base properties of the ground and excited states of Ruthenium(II) Bis(2,2'-bipyridine) 3-Carboxyl-2,2'-bipyridine
(American Chemical Society, 1996-11-20)Acid-base properties for ruthenium(II) bis(2,2'-bipyridine) 3-carboxyl-2,2'-bipyridine reveal a ground state pK(a) of 0.82 +/- 0.07 and an excited state pK(a) of 2.31 +/- 0.05, a 1.5 pH unit increase from the ground state. ... -
Actin polymerization is stimulated by actin cross-linking protein palladin
(Portland Press Limited, 2016-02-09)The actin scaffold protein palladin regulates both normal cell migration and invasive cell motility, processes that require the co-ordinated regulation of actin dynamics. However, the potential effect of palladin on actin ... -
Actin-induced dimerization of palladin promotes actin-bundling
(John Wiley & Sons, Inc., 2015-01)A subset of actin binding proteins is able to form crosslinks between two or more actin filaments, thus producing structures of parallel or networked bundles. These actin crosslinking proteins interact with actin through ... -
Addition of H2O and O2 to acetone and dimethylsulfoxide ligated uranyl(V) dioxocations
(American Chemical Society, 2009-03-19)Gas-phase complexes of the formula [UO2(lig)]+ (lig = acetone (aco) or dimethylsulfoxide (dmso)) were generated by electrospray ionization (ESI) and studied by tandem ion-trap mass spectrometry to determine the general ... -
Advances in structure determination by cryo-EM to unravel membrane-spanning pore formation
(John Wiley and Sons, 2018-08-20)The beta pore-forming proteins (-PFPs) are a large class of polypeptides that are produced by all Kingdoms of life to contribute to their species' own survival. Pore assembly is a sophisticated multi-step process that ... -
Advances in the use of cyclodextrins as chiral selectors in capillary electrokinetic chromatography: fundamentals and applications
(Springer Berlin Heidelberg, 2016-11)Capillary electrokinetic chromatography is generally recognized as a versatile and robust capillary electromigration technique for the separation of enantiomers. In this mode, one or more chiral selectors are added to the ... -
Affinity chromatography of glucose dehydrogenase
(Springer, 1988-01-15)Porcine liver beta-D-glucose dehydrogenase, a multi-functional protein, has been purified to apparent homogeneity. The enzyme has been separated from the endoplasmic reticulum using Triton X-114 and further purified using ...