Browsing CHEM Faculty Scholarship by Subject "West Nile virus"

Now showing items 1-2 of 2

Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives

Tiew, Kok-Chuan; Dou, Dengfeng; Teramoto, Tadahisa; Lai, Huiguo; Alliston, Kevin R.; Lushington, Gerald H.; Padmanabhan, Radhakrishnan; Groutas, William C. (Elsevier, 2012-02)

Two click chemistry-derived focused libraries based on the benz[d]isothiazol-3(2H)-one scaffold were synthesized and screened against Dengue virus and West Nile virus NS2B-NS3 proteases. Several compounds (4l, 7j-n) displayed ...
Inhibitors of Dengue Virus and West Nile Virus proteases based on the aminobenzamide scaffold

Aravapalli, Sridhar; Lai, Huiguo; Teramoto, Tadahisa; Alliston, Kevin R.; Lushington, Gerald H.; Ferguson, Eron L.; Padmanabhan, Radhakrishnan; Groutas, William C. (Elsevier, 2012-05-10)

Dengue and West Nile viruses (WNV) are mosquito-borne members of flaviviruses that cause significant morbidity and mortality. There is no approved vaccine or antiviral drugs for human use to date. In this study, a series ...