Browsing CHEM Faculty Scholarship by Subject "Viral 3C and 3C-like protease inhibitors"

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    • Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors 

      Prior, Allan M.; Kim, Yunjeong; Weerasekara, Sahani; Moroze, Meghan; Alliston, Kevin R.; Uy, Roxanne Adeline Z.; Groutas, William C.; Chang, Kyeong-Ok; Hua, Duy H. (Elsevier Ltd, 2013-12-01)
      A class of tripeptidyl transition state inhibitors containing a P1 glutamine surrogate, a P2 leucine, and a P3 arylalanines, was found to potently inhibit Norwalk virus replication in enzyme and cell based assays. An array ...