Browsing CHEM Faculty Scholarship by Subject "Magnetic Resonance Spectroscopy"
Now showing items 1-20 of 22
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3S-fluoroproline as a probe to monitor proline isomerization during protein folding by 19F-NMR
(Royal Society of Chemistry, 2009-06-21)Variable-temperature inversion transfer NMR is used to determine the kinetic and thermodynamic parameters of cis-trans isomerization of N-Ac-(3R) and (3S)-fluoroproline-OMe. -
Ascorbate based novel high affinity alternate reductants and competitive inhibitors of dopamine beta-monooxygenase
(Elsevier, 1994-04-15)A series of ascorbate derivatives has been used to examine the specificity and the chemistry of the reduction site of dopamine beta-monooxygenase (D beta M). Replacement of the 6-OH group of ascorbic acid with either bromine ... -
Biosynthetic incorporation of fluorohistidine into proteins in E. coli: a new probe of macromolecular structure
(John Wiley and Sons, 2005-12-01) -
Boronate affinity chromatography
(Springer, 1992-01-01) -
A convenient entry to C2- and C3-substituted gulono-gamma-lactone derivatives from L-ascorbic acid
(American Chemical Society, 2005-08-19)A convenient method to obtain unknown chiral C2- and C3-functionalized aldono-1,4-lactone derivatives starting from l-ascorbic acid, which would be valuable in the synthesis of derivatives of various pharmacologically ... -
Derivatives of 3-alkyl-N-hydroxysuccinimide: probing the effect of structure on bioactivity toward human leukocyte elastase
(Harwood Academic Publishers, 1994-02-01)A structure-activity relationship study was conducted in order to probe the nature of the interaction between some 3-alkyl-N-hydroxysuccinimide derivatives and human leukocyte elastase. The structural features in substituent ... -
Design, synthesis, and in vitro evaluation of potential West Nile virus protease inhibitors based on the 1-oxo-1,2,3,4-tetrahydroisoquinoline and 1-oxo-1,2-dihydroisoquinoline scaffolds
(American Chemical Society, 2010-11-08)The 1-oxo-1, 2, 3, 4-tetrahydroisoquinoline and 1-Oxo-1, 2-dihydroisoquinoline scaffolds were utilized in the design and solution phase synthesis of focused libraries of compounds for screening against West Nile Virus (WNV) ... -
Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners
(Elsevier, 1996-09-01)The inhibitory activity toward human leukocyte elastase (HLE), cathepsin G (Cat G), and proteinase 3 (PR 3) of a series of saccharin derivatives having a sulfinate leaving group was investigated. The results of this study ... -
Effect of axial ligation or pi-pi-type interactions on photochemical charge stabilization in "two-point" bound supramolecular porphyrin-fullerene conjugates
(John Wiley and Sons, 2005-07-18)Two types of structurally well-defined, self-assembled zinc porphyrin-fullerene conjugates were formed by "two-point" binding strategies to probe the effect of axial ligation or pi-pi-type interactions on the photochemical ... -
The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3
(Elsevier, 1995-02-01)The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide ... -
Inhibition of human leukocyte elastase by phosphate esters of N-hydroxysuccinimide and its derivatives: direct observation of a phosphorylated enzyme by 31P nuclear magnetic resonance spectroscopy
(American Chemical Society, 1991-04-30)A series of phosphate esters derived from N-hydroxysuccinimide and 3-alkyl-N-hydroxysuccinimide have been synthesized and found to be potent time-dependent irreversible inhibitors of human leukocyte elastase (HLE). The ... -
Ionic inhibitors of human leukocyte elastase: pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide
(John Wiley and Sons, 1990-10-01)A series of pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide has been synthesized; the compounds have been shown to be highly effective, time-dependent inactivators of human leukocyte elastase. ... -
Mechanism-based inhibition of human leukocyte elastase and cathepsin G by substituted dihydrouracils
(Elsevier, 1994-11-29)A series of dihydrouracil derivatives has been synthesized and investigated for their in vitro inhibitory activity toward human leukocyte elastase (HLE) and cathepsin G (Cath G). Alkyl [sulfonyl(oxy)] uracils 1-2 were found ... -
Microcapsules through polymer complexation. I: Complex coacervation of polymers containing a high charge density
(Elsevier, 1991-05-01)Acidic and basic methacrylate co- and ter-polymers based on (respectively) methacrylic acid (MAA) and dimethylaminoethyl methacrylate (DMAEMA) were prepared by solution free radical polymerization and structurally characterized ... -
Noncovalent inhibitors of human leukocyte elastase based on the 4-imidazolidinone scaffold
(Elsevier, 2003-11-17)A central problem associated with the design of enzyme inhibitors in general, and serine protease inhibitors in particular, is the identification of templates capable of binding to the active site of an enzyme in a predictable ... -
Photosynthetic reaction center mimicry: low reorganization energy driven charge stabilization in self-assembled cofacial zinc phthalocyanine dimer-fullerene conjugate
(American Chemical Society, 2009-07-01)By employing well-defined self-assembly methods, a biomimetic bacterial photosynthetic reaction center complex has been constructed, and photoinduced electron transfer originating in this supramolecular donor-acceptor ... -
Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives
(Elsevier, 2004-09-15)The design, synthesis, and in vitro biochemical evaluation of a class of mechanism-based inhibitors of human leukocyte elastase (HLE) that incorporate in their structure a 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold ... -
Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold
(American Chemical Society, 1997-04-22)We describe in this paper the structure-based design of a general class of heterocyclic mechanism-based inhibitors of the serine proteinases that embody in their structure a novel peptidomimetic scaffold (1,2,5-thiadiazo ... -
Studies on porphyrin-quinhydrone complexes: molecular recognition of quinone and hydroquinone in solution
(American Chemical Society, 2001-06-29)Free-base and zinc(II) porphyrins bearing either one, two, or four hydroquinone entities at the meso positions are shown to bind quinones in solutions via a quinhydrone pairing mechanism. Electrochemical studies reveal ...