Browsing CHEM Faculty Scholarship by Subject "Macromolecular crystallography"
Now showing items 1-3 of 3
-
Oxadiazole-based cell permeable macrocyclic transition state inhibitors of norovirus 3CL protease
(American Chemical Society, 2016-03-10)Human noroviruses are the primary causative agents of acute gastroenteritis and a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or ... -
Structure-guided design and optimization of dipeptidyl inhibitors of Norovirus 3CL protease. Structure-activity relationships and biochemical, x-ray crystallographic, cell-based, and in vivo studies
(American Chemical Society, 2015-04-09)Norovirus infection constitutes the primary cause of acute viral gastroenteritis. There are currently no vaccines or norovirus-specific antiviral therapeutics available for the management of norovirus infection. Norovirus ... -
Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease
(Elsevier, 2018-01-01)Acute nonbacterial gastroenteritis caused by noroviruses constitutes a global public health concern and a significant economic burden. There are currently no small molecule therapeutics or vaccines for the treatment of ...