Browsing CHEM Faculty Scholarship by Subject "Macrocyclic inhibitors"
Now showing items 1-4 of 4
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Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease
(Elsevier B.V., 2017-02-15)Norovirus infections have a major impact on public health worldwide, yet there is a current dearth of norovirus-specific therapeutics and prophylactics. This report describes the discovery of a novel class of macrocyclic ... -
Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease
(John Wiley and Sons, 2019-03-18)Human noroviruses are the primary cause of outbreaks of acute gastroenteritis worldwide. The problem is further compounded by the current lack of norovirus-specific antivirals or vaccines. Noroviruses have a single-stranded, ... -
Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies
(Elsevier B.V., 2016-08-25)Outbreaks of acute gastroenteritis caused by noroviruses constitute a public health concern worldwide. To date, there are no approved drugs or vaccines for the management and prophylaxis of norovirus infections. A potentially ... -
Structure-guided design, synthesis and evaluation of oxazolidinone-based inhibitors of norovirus 3CL protease
(Elsevier, 2018-01-01)Acute nonbacterial gastroenteritis caused by noroviruses constitutes a global public health concern and a significant economic burden. There are currently no small molecule therapeutics or vaccines for the treatment of ...