Now showing items 1-5 of 5

    • Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses 

      Kim, Yunjeong; Lovell, Scott; Tiew, Kok-Chuan; Mandadapu, Sivakoteswara Rao; Alliston, Kevin R.; Battaile, Kevin P.; Groutas, William C.; Chang, Kyeong-Ok (American Society of Microbiology, 2012-08-22)
      Phylogenetic analysis has demonstrated that some positive-sense RNA viruses can be classified into the picornavirus-like supercluster, which includes picornaviruses, caliciviruses, and coronaviruses. These viruses possess ...
    • Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics 

      Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Kankanamalage, Anushka C. Galasiti; Uy, Roxanne Adeline Z.; Alliston, Kevin R.; Lushington, Gerald H.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C. (Elsevier, 2013-11)
      The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme ...
    • Structure-guided design of conformationally constrained cyclohexane inhibitors of severe acute respiratory syndrome coronavirus-2 3cl protease 

      Dampalla, Chamandi S.; Kim, Yunjeong; Bickmeier, Naemi; Rathnayake, Athri D. (American Chemical Society, 2021-07-01)
      A series of nondeuterated and deuterated dipeptidyl aldehyde and masked aldehyde inhibitors that incorporate in their structure a conformationally constrained cyclohexane moiety was synthesized and found to potently inhibit ...
    • Structure-guided design of potent inhibitors of SARS-CoV-2 3CL protease: Structural, biochemical, and cell-based studies 

      Dampalla, Chamandi S.; Rathnayake, Athri D.; Perera, Krishani Dinali; Jesri, Abdul Rahman M.; Nguyen, Harry Nhat; Miller, Matthew J.; Thurman, Hayden A.; Zheng, Jian; Kashipathy, Maithri M.; Battaile, Kevin P.; Lovell, Scott; Perlman, Stanley (American Chemical Society, 2021-12-01)
      The COVID-19 pandemic is having a major impact on public health worldwide, and there is an urgent need for the creation of an armamentarium of effective therapeutics, including vaccines, biologics, and small-molecule ...
    • Structure-guided optimization of dipeptidyl inhibitors of Norovirus 3CL protease 

      Rathnayake, Athri D.; Kim, Yunjeong; Dampalla, Chamandi S.; Nguyen, Harry Nhat; Jesri, Abdul Rahman M.; Kashipathy, Maithri M.; Lushington, Gerald Henry; Battaile, Kevin P.; Lovell, Scott; Chang, Kyeong-Ok; Groutas, William C. (American Chemical Society, 2020-09-18)
      Acute gastroenteritis caused by noroviruses has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The disease impacts most severely immunocompromised patients, the elderly, ...