Browsing CHEM Faculty Scholarship by Subject "In Vitro"
Now showing items 1-8 of 8
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Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3
(Elsevier, 1996-08-15)Amino acid-derived phthalimide and saccharin derivatives have been investigated for their inhibitory activity toward the serine proteinases human leukocyte elastase, cathepsin G, and proteinase 3. The saccharin derivatives ... -
Characterization of a series of 3-amino-2-phenylpropene derivatives as novel bovine chromaffin vesicular monoamine transporter inhibitors
(American Chemical Society, 2003-06-19)A series of 3-amino-2-phenylpropene (APP) derivatives have been synthesized and characterized as novel competitive inhibitors, with K(i) values in the microM range, for the bovine chromaffin granule membrane monoamine ... -
Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032)
(Elsevier, 1997-04-28)The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex ... -
Ionic inhibitors of human leukocyte elastase: pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide
(John Wiley and Sons, 1990-10-01)A series of pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide has been synthesized; the compounds have been shown to be highly effective, time-dependent inactivators of human leukocyte elastase. ... -
Microcapsules through polymer complexation. I: Complex coacervation of polymers containing a high charge density
(Elsevier, 1991-05-01)Acidic and basic methacrylate co- and ter-polymers based on (respectively) methacrylic acid (MAA) and dimethylaminoethyl methacrylate (DMAEMA) were prepared by solution free radical polymerization and structurally characterized ... -
pH-induced alteration and oxidative destruction of heme in purified chromaffin granule cytochrome b(561): implications for the oxidative stress in catecholaminergic neurons
(American Chemical Society, 2003-04-01)The transmembrane hemoprotein, cytochrome b(561) (b(561)), in the neuroendocrine secretory vesicles is shown to shuttle electrons from the cytosolic ascorbate (Asc) to the intravesicular matrix to provide reducing equivalents ... -
Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study
(American Chemical Society, 2008-02-28)The active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), N-methyl-4-phenylpyridinium (MPP(+)), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease. Inhibition ...