Browsing CHEM Faculty Scholarship by Subject "Gastroenteritis"
Now showing items 1-2 of 2
-
Design, synthesis, and evaluation of novel prodrugs of transition state inhibitors of norovirus 3CL protease
(American Chemical Society, 2017-07-03)Ester and carbamate prodrugs of aldehyde bisulfite adduct inhibitors were synthesized in order to improve their pharmacokinetic and pharmacodynamic properties. The inhibitory activity of the compounds against norovirus ... -
Structure-guided design and optimization of dipeptidyl inhibitors of Norovirus 3CL protease. Structure-activity relationships and biochemical, x-ray crystallographic, cell-based, and in vivo studies
(American Chemical Society, 2015-04-09)Norovirus infection constitutes the primary cause of acute viral gastroenteritis. There are currently no vaccines or norovirus-specific antiviral therapeutics available for the management of norovirus infection. Norovirus ...