Browsing CHEM Faculty Scholarship by Issue Date
Now showing items 1-20 of 493
-
Non-aqueous titration of hydroxamic acids
(Elsevier, 1966-01-01)Benzohydroxamic acid is titrated with 0.1M tetrabutyl-anunonium hydroxide in nine non-aqueous solvents with three different indicating electrodes. The best results are obtained using dimethylformamide as solvent and ... -
Borate complexes of benzohydroxamic acid and some of its derivatives
(Elsevier, 1966-07-01)Ultraviolet spectrophotometric measurements in dilute aqueous solution give pK(a) values of 8.78, 8.27, 8.96 and 8.68, respectively, for benzohydroxamic, N-phenylbenzohydroxamic, p-methoxybenzohydroxamic and N-methyl-p-m ... -
Altered acetylcholinesterase activity (AChE) and maze performance of developing rats (Rattus norvegicus) following mesencephalic electrical brain stimulation
(Springer-Verlag, 1977-11-17)Cortical arousal was altered by electrical brain stimulation (EBS) to the mesencephalic ascending reticular formation beginning at 27 days of age and administered 2 h/day for either 14 or 28 days. Subjects receiving brain ... -
A microprocessor-controlled photon counter for pulsed optically detected magnetic resonance
(American Institute of Physics, 1979-08-01)In pulsed optically detected magnetic resonance (ODMR) spectroscopy, a lock-in amplifier is used to monitor the signal which is phase-matched to the duty cycle of an applied sequence of pulses. However, since the desired ... -
Affinity chromatography of glucose dehydrogenase
(Springer, 1988-01-15)Porcine liver beta-D-glucose dehydrogenase, a multi-functional protein, has been purified to apparent homogeneity. The enzyme has been separated from the endoplasmic reticulum using Triton X-114 and further purified using ... -
Results compared for tricyclic antidepressants as assayed by liquid chromatography and enzyme immunoassay
(P.B. Hoeber, 1988-11-01)The tricyclic antidepressants amitriptyline, nortriptyline, imipramine, and desipramine in serum of patients taking one of the drugs were quantified in two laboratories by high-performance liquid chromatography (HPLC) and ... -
High-performance liquid chromatographic analysis of DNA composition and DNA modification by chloroacetaldehyde
(Elsevier, 1988-12-23)The separation of common and modified deoxyribonucleosides derived from DNA hydrolyzates was examined under different chromatographic conditions on silica-based octadecyl (C18) columns, involving hydrophobic interactions ... -
Inhibition of human leukocyte elastase by derivatives of N-hydroxysuccinimide. A structure-activity-relationship study
(American Chemical Society, 1989-07-01)A series of compounds derived from 3-alkyl-N-hydroxysuccinimide have been synthesized and their inhibitory activity toward human leukocyte elastase has been investigated. Compounds having an isobutyl or isopropyl group at ... -
Hydantoin derivatives. A new class of inhibitors of human leukocyte elastase
(Informa Healthcare, 1990-01-01)Derivatives of hydantoin have been found to inactivate human leukocyte elastase irreversibly. Chymotrypsin and cathepsin G are also inhibited by these compounds. -
Inhibitors of human leukocyte proteinase-3
(American Chemical Society, 1990-04-01) -
Latent isocynate derivatives useful for deactivating enzymes
(United States Patent and Trademark Office, 1990-05-29)Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ... -
Ionic inhibitors of human leukocyte elastase: pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide
(John Wiley and Sons, 1990-10-01)A series of pyridinium and phenyl carboxylate derivatives of 3-alkyl-N-hydroxysuccinimide has been synthesized; the compounds have been shown to be highly effective, time-dependent inactivators of human leukocyte elastase. ... -
N,N,N',N'-tetramethyl-1,4-phenylenediamine: a facile electron donor and chromophoric substrate for dopamine beta-monooxygenase
(Elsevier, 1991-03-29)Dopamine beta-monooxygenase is shown to catalyze the oxidation of N,N,N',N'-tetramethyl-1,4-phenylenediamine (TMPD) to its cation radical in the presence of a regular substrate and molecular oxygen. The enzyme-mediated ... -
Inhibition of human leukocyte elastase by phosphate esters of N-hydroxysuccinimide and its derivatives: direct observation of a phosphorylated enzyme by 31P nuclear magnetic resonance spectroscopy
(American Chemical Society, 1991-04-30)A series of phosphate esters derived from N-hydroxysuccinimide and 3-alkyl-N-hydroxysuccinimide have been synthesized and found to be potent time-dependent irreversible inhibitors of human leukocyte elastase (HLE). The ... -
Microcapsules through polymer complexation. I: Complex coacervation of polymers containing a high charge density
(Elsevier, 1991-05-01)Acidic and basic methacrylate co- and ter-polymers based on (respectively) methacrylic acid (MAA) and dimethylaminoethyl methacrylate (DMAEMA) were prepared by solution free radical polymerization and structurally characterized ... -
Microcapsules through polymer complexation. II. By complex coacervation of polymers containing a low charge density
(Elsevier, 1991-07-01)Relationships between ionizable group content, structure and molecular weight, solubility and solution behaviour, and the efficacy of ionic complex formation through complex coacervation, have been established for a range ... -
Continuous spectrophotometric assays for dopamine beta-monooxygenase based on two novel electron donors: N,N-dimethyl-1,4-phenylenediamine and 2-aminoascorbic acid
(Elsevier, 1991-09-02)Based on the novel chromophoric electron donors, N,N-dimethyl-1,4-phenylenediamine (DMPD) and 2-amino-2-deoxy-L-ascorbic acid (2-aminoascorbic acid), two sensitive, convenient, and continuous spectrophotometric assays for ... -
Boronate affinity chromatography
(Springer, 1992-01-01) -
Inhibitors of human neutrophil cathepsin G: structural and biochemical studies
(Elsevier, 1992-04-01)The interaction of a series of sulfonate and phosphate esters derived from N-hydroxysuccinimide with human leukocyte cathepsin G was investigated. The synthesized compounds were found to be time-dependent inhibitors of the ... -
Enantioselective inhibition of human leukocyte elastase
(Elsevier, 1992-08-15)(RS)-Diethyl-2-benzyl-succinate was resolved using alpha-chymotrypsin. The two enantiomers were then elaborated to yield (S)-(+) and (R)-(-)-3-benzyl-N-[(methyl-sulfonyl)oxy]succinimide and the inhibitory activity of the ...