Browsing CHEM Faculty Scholarship by Author "Yu, Hongyi"
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1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases Groutas, William C.; Epp, Jeffrey B.; Kuang, Rongze; Ruan, Sumei; Chong, Lee S.; Venkataraman, Radhika; Tu, Juan; He, Shu; Yu, Hongyi; Fu, Qingfong; Li, Yue He; Truong, Tien M.; Vu, Nga T. (Elsevier, 2001-01-01)The 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold (I) embodies a motif that allows it to dock to the active site of (chymo)trypsin-like proteases in a predictable and substrate-like fashion. Consequently, inhibitors ...
Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold Groutas, William C.; Schechter, Norman M.; He, Shu; Yu, Hongyi; Huang, Peng; Tu, Juan (Elsevier, 1999-08-02)A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase.
Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives Lai, Zhong; Gan, Xiangdong; Wei, Liuqing; Alliston, Kevin R.; Yu, Hongyi; Li, Yue He; Groutas, William C. (Elsevier, 2004-09-15)The design, synthesis, and in vitro biochemical evaluation of a class of mechanism-based inhibitors of human leukocyte elastase (HLE) that incorporate in their structure a 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold ...
Potential protease inhibitors based on a functionalized cyclic sulfamide scaffold Zhong, Jiaying; Gan, Xiangdong; Alliston, Kevin R.; Lai, Zhong; Yu, Hongyi; Groutas, Christopher S.; Wong, Tzutshin; Groutas, William C. (American Chemical Society, 2004-07-01)Exploratory studies related to the design and synthesis of functionalized cyclic sulfamides (I) as potential inhibitors of proteolytic enzymes were carried out. The structural motif and three diversity sites embodied in ...