Now showing items 1-2 of 2

    • Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides 

      Li, Yi; Yang, Qingliang; Dou, Dengfeng; Alliston, Kevin R.; Groutas, William C. (Elsevier, 2008-01-15)
      The interaction of a series of 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides with neutrophil-derived serine proteases was investigated. The nature of the amino acid component, believed to be oriented toward the ...
    • Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents 

      Yang, Qingliang; Li, Yi; Dou, Dengfeng; Gan, Xiangdong; Mohan, Swathi; Groutas, Christopher S.; Stevenson, Laura E.; Lai, Zhong; Alliston, Kevin R.; Zhong, Jiaying; Williams, Todd D.; Groutas, William C. (Elsevier, 2008-07-15)
      A new class of carbamylating agents based on the cyclosulfamide scaffold is reported. These compounds were found to be efficient time-dependent inhibitors of human neutrophil elastase (HNE). Exploitation of the three sites ...