Browsing CHEM Faculty Scholarship by Author "Fu, Qingfong"

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1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases

Groutas, William C.; Epp, Jeffrey B.; Kuang, Rongze; Ruan, Sumei; Chong, Lee S.; Venkataraman, Radhika; Tu, Juan; He, Shu; Yu, Hongyi; Fu, Qingfong; Li, Yue He; Truong, Tien M.; Vu, Nga T. (Elsevier, 2001-01-01)

The 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold (I) embodies a motif that allows it to dock to the active site of (chymo)trypsin-like proteases in a predictable and substrate-like fashion. Consequently, inhibitors ...
Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase

Dou, Dengfeng; He, Guijia; Kuang, Rongze; Fu, Qingfong; Venkataraman, Radhika; Groutas, William C. (Elsevier, 2010-09-15)

A structurally-diverse series of carboxylate derivatives based on the 1,2,5-thiadiazolidin-one 1,1 dioxide scaffold were synthesized and used to probe the S' subsites of human neutrophil elastase (HNE) and neutrophil ...