Browsing CHEM Faculty Scholarship by Author "Frieden, Carl"

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Catalysis of protein folding by chaperones in pathogenic bacteria

Bann, James G.; Pinkner, Jerome S.; Frieden, Carl; Hultgren, Scott J. (2004-12-14)

Molecular chaperones are thought to inhibit off-pathway interactions such as aggregation from occurring without influencing the on-pathway formation of native structure. Here, we present a mechanism whereby the family of ...
Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli

Justice, Sheryl S.; Hunstad, David A.; Harper, Jill R.; Duguay, Amy R.; Pinkner, Jerome S.; Bann, James G.; Frieden, Carl; Silhavy, Thomas J.; Hultgren, Scott J. (American Society for Microbiology, 2005-08-31)

In Escherichia coli, FkpA, PpiA, PpiD, and SurA are the four known periplasmic cis-trans prolyl isomerases. These isomerases facilitate proper protein folding by increasing the rate of transition of proline residues between ...