Browsing CHEM Faculty Scholarship by Author "Balasooriya, Inoka S."

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Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study

Wimalasena, D. Shyamali; Perera, Rohan P.; Heyen, Bruce J.; Balasooriya, Inoka S.; Wimalasena, Kandatege (American Chemical Society, 2008-02-28)

The active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), N-methyl-4-phenylpyridinium (MPP(+)), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease. Inhibition ...