Browsing CHEM Faculty Scholarship by Author "Andra, Kiran K."
Now showing items 1-5 of 5
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2-Fluoro-l-histidine
Andra, Kiran K.; Bullinger, John C.; Bann, James G.; Eichhorn, David M. (International Union of Crystallography, 2010-01-01)The title compound, C(6)H(8)FN(3)O(2), an analog of histidine, shows a reduced side-chain pK(a) (ca 1). The title structure exhibits a shortening of the bond between the proximal ring N atom and the F-substituted ring C ... -
Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine
Iyer, Vidyashankara; Hu, Lei; Schante, Carole E.; Vance, David; Chadwick, Chrystal; Jain, Nishant Kumar; Brey, Robert N.; Joshi, Sangeeta B.; Volkin, David B.; Andra, Kiran K.; Bann, James G.; Mantis, Nicholas J.; Middaugh, C. Russell (Landes Bioscience, 2013-11)Dominant negative inhibitor (DNI) is a translocation-deficient homolog of recombinant protective antigen of Bacillus anthracis that is a candidate for a next generation anthrax vaccine. This study demonstrates that the ... -
Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue
Hu, Lei; Joshi, Sangeeta B.; Andra, Kiran K.; Thakkar, Santosh V.; Volkin, David B.; Bann, James G.; Middaugh, C.R. (Wiley-Blackwell, 2012-11)Protective antigen (PA) is the primary protein antigenic component of both the currently used anthrax vaccine and related recombinant vaccines under development. An analogue of recombinant PA (2-FHis rPA) has been recently ... -
pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2
Rajapaksha, Maheshinie; Lovell, Scott; Janowiak, Blythe E.; Andra, Kiran K.; Battaile, Kevin P.; Bann, James G. (Wiley-Blackwell, 2012-10)The anthrax protective antigen (PA) binds to the host cellular receptor capillary morphogenesis protein 2 (CMG2) with high affinity. To gain a better understanding of how pH may affect binding to the receptor, we have ... -
Structure of the anthrax protective antigen D425A dominant negative mutant reveals a stalled intermediate state of pore maturation
Scott, Harry; Huang, Wei; Andra, Kiran K.; Mamillapalli, Sireesha; Gonti, Srinivas; Day, Alexander; Zhang, Kaiming; Mehzabeen, Nurjahan; Battaile, Kevin P.; Raju, Anjali; Lovell, Scott; Bann, James G.; Taylor, Derek J. (Elsevier, 2022-05-15)The tripartite protein complex produced by anthrax bacteria (Bacillus anthracis) is a member of the AB family of β-barrel pore-forming toxins. The protective antigen (PA) component forms an oligomeric prepore that assembles ...