Browsing CHEM Faculty Scholarship by Author "Anderson, David E."

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    • Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation 

      Wimalasena, D. Shyamali; Cramer, John C.; Janowiak, Blythe E.; Juris, Stephen J.; Melnyk, Roman A.; Anderson, David E.; Kirk, Kenneth L.; Collier, R. John; Bann, James G. (American Chemical Society, 2007-12-25)
      The action of anthrax toxin relies in part upon the ability of the protective antigen (PA) moiety to form a heptameric pore in the endosomal membrane, providing a portal for entry of the enzymic moieties of the toxin into ...

    • Monitoring anthrax toxin receptor dissociation from the protective antigen by NMR 

      Rajapaksha, Maheshinie; Eichler, Jack F.; Hajduch, Jan; Anderson, David E.; Kirk, Kenneth L.; Bann, James G. (John Wiley and Sons, 2009-01-01)
      The binding of the Bacillus anthracis protective antigen (PA) to the host cell receptor is the first step toward the formation of the anthrax toxin, a tripartite set of proteins that include the enzymatic moieties edema ...