Browsing CHEM Faculty Scholarship by Issue Date
Now showing items 41-60 of 484
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Crystal structure, physical and photophysical properties of a platinum(II) complex coordinated to the biphenyl dianion and cyclooctadiene
(Kluwer Academic Publishers-Plenum Publishers, 1996-08)The complex, Pt(bph)(COD), where bph is the biphenyl dianion and COD is 1,5-cyclooctadiene, crystallizes in the orthorhombic space groupPbca witha=12.178(4) Å,b=9.693(3) Å andc=25.344(9) Å andZ=8. The Pt−C distances to the ... -
Amino acid-derived phthalimide and saccharin derivatives as inhibitors of human leukocyte elastase, cathepsin G, and proteinase 3
(Elsevier, 1996-08-15)Amino acid-derived phthalimide and saccharin derivatives have been investigated for their inhibitory activity toward the serine proteinases human leukocyte elastase, cathepsin G, and proteinase 3. The saccharin derivatives ... -
Serine protease inhibitors
(United States Patent and Trademark Office, 1996-08-27)Isothiazolidin-3-one-1,1 dioxide, 3-oxo-1,2,5-thiadiazolidine-1,1,-dioxide and derivatives thereof, reduce or inhibit the activity of serine proteases. Such compounds are useful as anti-inflammatory and anti-metastatic agents. -
Design, synthesis, and in vitro inhibitory activity toward human leukocyte elastase, cathepsin G, and proteinase 3 of saccharin-derived sulfones and congeners
(Elsevier, 1996-09-01)The inhibitory activity toward human leukocyte elastase (HLE), cathepsin G (Cat G), and proteinase 3 (PR 3) of a series of saccharin derivatives having a sulfinate leaving group was investigated. The results of this study ... -
Electrochemistry and spectral characterization of oxidized and reduced (TPPBr(x)())FeCl where TPPBr(x)() is the dianion of beta-brominated-pyrrole tetraphenylporphyrin and x varies from 0 to 8
(American Chemical Society, 1996-09-11)The electrochemistry and spectroelectrochemistry of (TPPBr(x)())FeCl (TPPBr(x)() is the dianion of beta-brominated-pyrrole tetraphenylporphyrin and x = 0-8) were examined in PhCN containing tetra-n-butylammonium perchlorate ... -
Spectral and electrochemical investigations on the "tail-on" and "tail-off" mechanism in pyridine covalently bound zinc(II) porphyrins
(American Chemical Society, 1996-09-11) -
Reduction of dopamine beta-monooxygenase. A unified model for apparent negative cooperativity and fumarate activation
(American Society for Biochemistry and Molecular Biology, 1996-10-18)The interactions of reductants with dopamine beta-monooxygenase (DbetaM) were examined using two novel classes of reductants. The steady-state kinetics of the previously characterized DbetaM reductant, N,N-dimethyl-1,4-p ... -
Comparison of physical and photophysical properties of monometallic and bimetallic ruthenium(II) complexes containing structurally altered diimine ligands
(American Chemical Society, 1996-11-06)The physical and photophysical properties of a series of monometallic, [Ru(bpy)(2)(dmb)](2+), [Ru(bpy)(2)(BPY)](2+), [Ru(bpy)(Obpy)](2+) and [Ru(bpy)(2)(Obpy)](2+), and bimetallic, [{Ru(bpy)(2)}(2)(BPY)](4+) and ... -
Acid-base properties of the ground and excited states of Ruthenium(II) Bis(2,2'-bipyridine) 3-Carboxyl-2,2'-bipyridine
(American Chemical Society, 1996-11-20)Acid-base properties for ruthenium(II) bis(2,2'-bipyridine) 3-carboxyl-2,2'-bipyridine reveal a ground state pK(a) of 0.82 +/- 0.07 and an excited state pK(a) of 2.31 +/- 0.05, a 1.5 pH unit increase from the ground state. ... -
Application of spherical and other polymers in capillary zone electrophoresis: separation of antiviral drugs and deoxyribonucleoside phosphates by different principles
(Elsevier, 1996-12-20)Soluble polymers of linear chains with limited branching and spherical polymers (limit dextrins and sucrose, such as Dextran and Ficoll (Pharmacia Chemicals), yielding lower viscosities, are examined here for the separation ... -
Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold
(American Chemical Society, 1997-04-22)We describe in this paper the structure-based design of a general class of heterocyclic mechanism-based inhibitors of the serine proteinases that embody in their structure a novel peptidomimetic scaffold (1,2,5-thiadiazo ... -
Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032)
(Elsevier, 1997-04-28)The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex ... -
Acid-Base and Electrochemical Properties of the MLCT Excited States and One-Electron-Reduced Forms of Ruthenium(II) Complexes Containing 2-(2'-Pyridyl)pyrimidine and 2,2'-Bipyridine in Aqueous Solution
(American Chemical Society, 1997-05-21)The acid-base and electrochemical properties of the MLCT excited states and the one-electron-reduced forms of the three Ru(bpy)(3)(-)()(p)()(pypm)(p)()(2+) complexes, where bpy = 2,2'-bipyridine, pypm = 2-(2'-pyridyl)pyrimidine, ... -
Chiral multisubstrate inhibitors of dopamine beta-monooxygenase: evidence for dual modes of interaction
(American Chemical Society, 1997-06-10)The electronic and steric constraints of the dopamine beta-monooxygenase (DbetaM; E.C. 1.14.17.1) active site were studied using a series of chiral bisubstrate inhibitors. The (R) and (S) enantiomers of 5-phenyl-2-thiooxazolidone ... -
Prediction of selectivity for the separation of double-stranded DNA fragments in electrophoresis
(ISC Technical Publications, 1997-09-01)The electrophoretic resolution (selectivity) of double-stranded DNA (dsDNA) restriction fragments is studied for different organisms (phi X174, lambda phage, and pGEM-3 plasmids) by various separation and detection methods. ... -
Synthetic strategies for the preparation of precursor polymers and of microcapsules suitable for cellular entrapment by polyelectrolyte complexation of those polymers
(John Wiley and Sons, 1997-12-31)The production of microcapsules suitable for the entrapment of mammalian cell by means of polyelectrolyte complexation has, of a necessity, led to the development of novel strategies for the preparation of relatively ... -
Use of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds in the design of potent inhibitors of serine proteinases
(Elsevier, 1998-03-03)The attachment of a phosphate leaving group to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds was found to yield highly potent, time-dependent inhibitors of human leukocyte elastase ... -
Comparison of solid-state and solution photophysical properties of a platinum(II) biphenyl dicarbonyl complex: a multiple-state emission study
(American Chemical Society, 1998-03-23)Pt(bph)(CO)(2), where bph is the biphenyl dianion, displays multiple emission by altering the temperature, solvent, or its state. Emission spectra and emission quantum yields are concentration and excitation wavelength ... -
Syntheses and electrochemical, photophysical, and photochemical properties of Ruthenium(II) 4,5-Diazafluorenone complexes and their ketal derivatives
(ACS Publications, 1998-04-03)A series of ruthenium(II) complexes of the types [Ru(bpy)n(dafo)3-n]2+ and [Ru(bpy)n(dafo-ketal)3-n]2+, where n varies between 0 and 3 and dafo is 4,5-diazafluoren-9-one, were synthesized, and their chemical, physical, and ... -
Preparation, Purification, and Characterization of Binuclear Ruthenium(II) Complexes: Bridging Ligands Based on Diazafluorenes
(American Chemical Society, 1998-05-04)A series of bimetallic complexes of ruthenium(II) bridged by heterocyclic ligands formed by the condensation of 4,5-diazafluoren-9-one with various diamines, hydrazine, 1,4-phenylenediamine, benzidine, and 4,4'-methylenedianiline, ...