Browsing CHEM Faculty Scholarship by Title
Now showing items 485-491 of 491
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Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3
(Elsevier, 2010-02-01)The S' subsites of human neutrophil proteinase 3 (Pr 3) were probed by constructing diverse libraries of compounds based on the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide using combinational and click chemistry methods. The ... -
Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates
(Elsevier, 2000-05-01)A series of carboxylate derivatives based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide and isothiazolidin-3-one 1,1 dioxide scaffolds has been synthesized and the inhibitory profile of these compounds toward human leukocyte ... -
Valence tautomerism induced nucleophilic ipso substitution in a coordinated tetrabromocatecholate ligand and diverse catalytic activity mimicking the function of phenoxazinone synthase
(Elsevier B.V., 2016-02)Two new manganese(III) complexes, [pyH][Mn(Br(4)Cat)(2)(PY)1 (1) and [Mn(Br(4)Cat)(Br(3)PYCat)(PY)(2)] (2), where py is pyridine, Br(4)CatH(2) is tetrabromocatechol and Br(3)pyCatH(2) is 3,5,6-tribromo-4-pyridiniumcatechol, ... -
Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study
(American Chemical Society, 2008-02-28)The active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), N-methyl-4-phenylpyridinium (MPP(+)), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease. Inhibition ... -
Vesicular monoamine transporters: structure-function, pharmacology, and medicinal chemistry
(John Wiley and Sons, 2011-07-01)Vesicular monoamine transporters (VMAT) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. Two closely related VMATs with distinct pharmacological properties and tissue ... -
Viral and fungal inhibitors
(United States Patent and Trademark Office, 2013-08-20)Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, ... -
X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives
(American Chemical Society, 2008-04-10)The mechanism of action of a general class of mechanism-based inhibitors of serine proteases, including human neutrophil elastase (HNE), has been elucidated by determining the X-ray crystal structure of an enzyme-inhibitor ...