Browsing CHEM Faculty Scholarship by Title
Now showing items 284-303 of 496
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Middle-down proteomic analyses with Ion mobility separations of endogenous isomeric proteoforms
(NLM (Medline), 2020-01-14)Biological functions of many proteins are governed by post-translational modifications (PTMs). In particular, the rich PTM complement in histones controls the gene expression and chromatin structure with major health ... -
Mode of substrate interaction and energetics of carbon-oxygen bond formation of the dopamine beta-monooxygenase reaction
(American Chemical Society, 1999-11-09)Previous studies have shown that the dopamine beta-monooxygenase (DbetaM; E.C. 1.14.17.1)/1-(2-aminoethyl)-1,4-cyclohexadiene (CHDEA) reaction partitions between side chain and ring H-abstraction to produce the ... -
Molecular modeling of cetylpyridinium bromide, a cationic surfactant, in solutions and micelle
(American Chemical Society, 2015-11-10)Cationic surfactants are widely used in biological and industrial processes. Notably, surfactants with pyridinium salts, such as cetylpyridinium bromide (CPB), have diverse applications. The cetylpyridium cation has a ... -
Molecular structure characterization by isotopic splitting in nonlinear ion mobility spectra
(American Chemical Society, 2018-01-02)Nearly all compounds comprise numerous isotopologues ensuing from stable natural isotopes for constituent elements. The consequent isotopic envelopes in mass spectra can reveal the ion stoichiometry but not geometry. We ... -
Molecular triads composed of ferrocene, C60, and nitroaromatic entities: electrochemical, computational, and photochemical investigations
(John Wiley and Sons, 2002-12-27)Synthesis and physicochemical characterization of a series of molecular triads composed of ferrocene, C(60), and nitroaromatic entities are reported. Electrochemical studies revealed multiple redox processes involving all ... -
Monitoring anthrax toxin receptor dissociation from the protective antigen by NMR
(John Wiley and Sons, 2009-01-01)The binding of the Bacillus anthracis protective antigen (PA) to the host cell receptor is the first step toward the formation of the anthrax toxin, a tripartite set of proteins that include the enzymatic moieties edema ... -
Mono- and di-nuclear nickel(II) complexes with mixed N/S-donor ligands: Syntheses, structures and physical properties
(Elsevier, 2012-05-03)Two new Ni(II) complexes are reported with tridentate thiosemicarbazone ligands derived from Schiff-base condensation with phenylthiosemicarbazide. Complex 1, a novel dinuclear Ni(II) complex of a SNS ligand synthesized ... -
Multi-stage tandem mass spectrometry of metal cationized leucine enkephalin and leucine enkephalin amide
(John Wiley and Sons, 2002-01-01)We have examined the multi-stage collision induced dissociation (CID) of metal cationized leucine enkephalin, leucine enkephalin amide, and the N-acetylated versions of the peptides using ion trap mass spectrometry. In ... -
Multi-triphenylamine-substituted porphyrin-fullerene conjugates as charge stabilizing "antenna-reaction center" mimics
(American Chemical Society, 2007-09-06)A new concept of charge stabilization via delocalization of the pi-cation radical species over the donor macrocycle substituents in a relatively simple donor-acceptor bearing multimodular conjugates is reported. The newly ... -
Myopalladin promotes muscle growth through modulation of the serum response factor pathway
(Wiley Blackwell, 2019-10-24)Background: Myopalladin (MYPN) is a striated muscle-specific, immunoglobulin-containing protein located in the Z-line and I-band of the sarcomere as well as the nucleus. Heterozygous MYPN gene mutations are associated with ... -
Myopalladin's role in cardiac muscle function and disease
(Federation of American Societies for Experimental Biology, 2017-04)Decades of research have provided fundamental insight into the human heart’s structure and function. Yet, most cardiac malformations remain a mystery as scientists and clinicians continue to examine how inherited mutations ... -
N,N,N',N'-tetramethyl-1,4-phenylenediamine: a facile electron donor and chromophoric substrate for dopamine beta-monooxygenase
(Elsevier, 1991-03-29)Dopamine beta-monooxygenase is shown to catalyze the oxidation of N,N,N',N'-tetramethyl-1,4-phenylenediamine (TMPD) to its cation radical in the presence of a regular substrate and molecular oxygen. The enzyme-mediated ... -
N-methyl-4-phenylpyridinium scaffolds containing lipophilic compounds are potent complex i inhibitors and selective dopaminergic toxins
(ACS, 2019-04-01)Although the exact cause or causes of Parkinson's disease (PD) are not fully understood, it is believed that environmental factors play a major role. The discovery that a synthetic chemical, 1-methyl-4-phenyl-1,2,3,6-tet ... -
Near unity photon-to-electron conversion efficiency of photoelectrochemical cells built on cationic water-soluble porphyrins electrostatically decorated onto thin-film nanocrystalline SnO2 surface
(American Chemical Society, 2011-07-01)Thin transparent SnO(2) films have been surface modified with cationic water-soluble porphyrins for photoelectrochemical investigations. Free-base and zinc(II) derivatives of three types of cationic water-soluble porphyrins, ... -
Near-IR excitation transfer and electron transfer in a BF2-chelated dipyrromethane-azadipyrromethane dyad and triad
(WILEY-V C H VERLAG GMBH, 2012-04)A molecular dyad and triad, comprised of a known photosensitizer, BF2-chelated dipyrromethane (BDP), covalently linked to its structural analog and near-IR emitting sensitizer, BF2-chelated tetraarylazadipyrromethane (ADP), ... -
Neutrophil elastase inhibitors
(Informa Healthcare, 2011-03-01)INTRODUCTION: Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health problem. There is currently an urgent and unmet need for the development of small molecule therapeutics capable of blocking and/or ... -
New insights into the dynamics of zwitterionic micelles and their hydration waters by gigahertz-to-terahertz dielectric spectroscopy
(American Chemical Society, 2016-10-20)Gigahertz-to-terahertz spectroscopy of macromolecules in aqueous environments provides an important approach for identifying their global and transient molecular structures, as well as directly assessing hydrogen-bonding. ... -
New trisubstituted cyanopyrazoles and cyanoscorpionates
(Elsevier B.V., 2017-03-29)New syntheses are reported to give pyrazoles with cyano substituents at the 4-position of the pyrazole ring and ethyl or isopropyl substituents at the 3-position, as well as pyrazoles with cyano substituents at the 4-position ... -
Newly identified C–H⋯O hydrogen bond in histidine
(The Royal Society of Chemistry, 2022-06-19)New Cδ–H⋯O histidine hydrogen bonding interactions in various proteins are identified by neutron diffraction and computationally characterized. Neutron diffraction data shows several H-bond motifs with the Cδ–H moiety in ... -
Ni complexes of N2S ligands with amine/imine and amine/amide donors with relevance to the active site of Ni superoxide dismutase
(Elsevier, 2018-05-01)A series of Ni complexes of the form [Ni((NNS)-S-Im)(RS)] ((NNS)-S-Im = (2-(N-(dimethylaminoethyl)iminomethyl) benzenethiolate; R = phenyl, 4-nitrophenyl, 4-fluorophenyl, 4-chlorophenyl, 4-t-butylphenyl, t-butyl), as well ...