Browsing CHEM Faculty Scholarship by Title
Now showing items 283-302 of 485
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Monitoring anthrax toxin receptor dissociation from the protective antigen by NMR
(John Wiley and Sons, 2009-01-01)The binding of the Bacillus anthracis protective antigen (PA) to the host cell receptor is the first step toward the formation of the anthrax toxin, a tripartite set of proteins that include the enzymatic moieties edema ... -
Mono- and di-nuclear nickel(II) complexes with mixed N/S-donor ligands: Syntheses, structures and physical properties
(Elsevier, 2012-05-03)Two new Ni(II) complexes are reported with tridentate thiosemicarbazone ligands derived from Schiff-base condensation with phenylthiosemicarbazide. Complex 1, a novel dinuclear Ni(II) complex of a SNS ligand synthesized ... -
Multi-stage tandem mass spectrometry of metal cationized leucine enkephalin and leucine enkephalin amide
(John Wiley and Sons, 2002-01-01)We have examined the multi-stage collision induced dissociation (CID) of metal cationized leucine enkephalin, leucine enkephalin amide, and the N-acetylated versions of the peptides using ion trap mass spectrometry. In ... -
Multi-triphenylamine-substituted porphyrin-fullerene conjugates as charge stabilizing "antenna-reaction center" mimics
(American Chemical Society, 2007-09-06)A new concept of charge stabilization via delocalization of the pi-cation radical species over the donor macrocycle substituents in a relatively simple donor-acceptor bearing multimodular conjugates is reported. The newly ... -
Myopalladin promotes muscle growth through modulation of the serum response factor pathway
(Wiley Blackwell, 2019-10-24)Background: Myopalladin (MYPN) is a striated muscle-specific, immunoglobulin-containing protein located in the Z-line and I-band of the sarcomere as well as the nucleus. Heterozygous MYPN gene mutations are associated with ... -
Myopalladin's role in cardiac muscle function and disease
(Federation of American Societies for Experimental Biology, 2017-04)Decades of research have provided fundamental insight into the human heart’s structure and function. Yet, most cardiac malformations remain a mystery as scientists and clinicians continue to examine how inherited mutations ... -
N,N,N',N'-tetramethyl-1,4-phenylenediamine: a facile electron donor and chromophoric substrate for dopamine beta-monooxygenase
(Elsevier, 1991-03-29)Dopamine beta-monooxygenase is shown to catalyze the oxidation of N,N,N',N'-tetramethyl-1,4-phenylenediamine (TMPD) to its cation radical in the presence of a regular substrate and molecular oxygen. The enzyme-mediated ... -
N-methyl-4-phenylpyridinium scaffolds containing lipophilic compounds are potent complex i inhibitors and selective dopaminergic toxins
(ACS, 2019-04-01)Although the exact cause or causes of Parkinson's disease (PD) are not fully understood, it is believed that environmental factors play a major role. The discovery that a synthetic chemical, 1-methyl-4-phenyl-1,2,3,6-tet ... -
Near unity photon-to-electron conversion efficiency of photoelectrochemical cells built on cationic water-soluble porphyrins electrostatically decorated onto thin-film nanocrystalline SnO2 surface
(American Chemical Society, 2011-07-01)Thin transparent SnO(2) films have been surface modified with cationic water-soluble porphyrins for photoelectrochemical investigations. Free-base and zinc(II) derivatives of three types of cationic water-soluble porphyrins, ... -
Near-IR excitation transfer and electron transfer in a BF2-chelated dipyrromethane-azadipyrromethane dyad and triad
(WILEY-V C H VERLAG GMBH, 2012-04)A molecular dyad and triad, comprised of a known photosensitizer, BF2-chelated dipyrromethane (BDP), covalently linked to its structural analog and near-IR emitting sensitizer, BF2-chelated tetraarylazadipyrromethane (ADP), ... -
Neutrophil elastase inhibitors
(Informa Healthcare, 2011-03-01)INTRODUCTION: Chronic obstructive pulmonary disease (COPD) constitutes a worldwide health problem. There is currently an urgent and unmet need for the development of small molecule therapeutics capable of blocking and/or ... -
New insights into the dynamics of zwitterionic micelles and their hydration waters by gigahertz-to-terahertz dielectric spectroscopy
(American Chemical Society, 2016-10-20)Gigahertz-to-terahertz spectroscopy of macromolecules in aqueous environments provides an important approach for identifying their global and transient molecular structures, as well as directly assessing hydrogen-bonding. ... -
New trisubstituted cyanopyrazoles and cyanoscorpionates
(Elsevier B.V., 2017-03-29)New syntheses are reported to give pyrazoles with cyano substituents at the 4-position of the pyrazole ring and ethyl or isopropyl substituents at the 3-position, as well as pyrazoles with cyano substituents at the 4-position ... -
Newly identified C–H⋯O hydrogen bond in histidine
(The Royal Society of Chemistry, 2022-06-19)New Cδ–H⋯O histidine hydrogen bonding interactions in various proteins are identified by neutron diffraction and computationally characterized. Neutron diffraction data shows several H-bond motifs with the Cδ–H moiety in ... -
Ni complexes of N2S ligands with amine/imine and amine/amide donors with relevance to the active site of Ni superoxide dismutase
(Elsevier, 2018-05-01)A series of Ni complexes of the form [Ni((NNS)-S-Im)(RS)] ((NNS)-S-Im = (2-(N-(dimethylaminoethyl)iminomethyl) benzenethiolate; R = phenyl, 4-nitrophenyl, 4-fluorophenyl, 4-chlorophenyl, 4-t-butylphenyl, t-butyl), as well ... -
Non-aqueous titration of hydroxamic acids
(Elsevier, 1966-01-01)Benzohydroxamic acid is titrated with 0.1M tetrabutyl-anunonium hydroxide in nine non-aqueous solvents with three different indicating electrodes. The best results are obtained using dimethylformamide as solvent and ... -
Noncovalent inhibitors of human leukocyte elastase based on the 4-imidazolidinone scaffold
(Elsevier, 2003-11-17)A central problem associated with the design of enzyme inhibitors in general, and serine protease inhibitors in particular, is the identification of templates capable of binding to the active site of an enzyme in a predictable ... -
NOR and AND logic gates based on supramolecular porphyrin-fullerene conjugates
(American Chemical Society, 2010-02-05)Supramolecular porphyrin-fullerene conjugates are employed to build NOR and AND logic gates. A crown ether appended zinc porphyrin and an imidazole or an alkyl ammonium functionalized fullerene are utilized. Quenching of ... -
A novel BF(2)-chelated azadipyrromethene-fullerene dyad: synthesis, electrochemistry and photodynamics
(Royal Society of Chemistry, 2012)The synthesis, structure, electrochemistry and photodynamics of a BF2-chelated azadipyrromethene–fullerene dyad are reported in comparison with BF2-chelated azadipyrromethene without fullerene. The attachment of fullerene ... -
Novel fragmentation pathway for CID of (b(n) - 1 + Cat)+ ions from model, metal cationized peptides
(Springer, 2005-08-01)We report a new fragmentation pathway for the CID of (b3 - 1 + Cat)+ product ions derived from the model peptide AXAG, where X = beta-alanine, gamma-aminobutyric acid, epsilon-amino-n-caproic acid, or 4-aminomethylbenzoic ...