Browsing CHEM Faculty Scholarship by Title
Now showing items 274-293 of 496
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Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding
(Elsevier, 2009-05-15)A series of mechanism-based inhibitors designed to interact with the S' subsites of serine proteases was synthesized and their inhibitory activity toward the closely-related serine proteases human neutrophil elastase (HNE) ... -
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement
(Elsevier, 1993-08-16)Neutrophil-derived mediators such as, for example, the serine proteinase elastase, cathepsin G and proteinase 3, play a critical role in inflammatory lung disease. This report describes the design, synthesis and in vitro ... -
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain
(Nature Publishing Group, 2016-02-16)Amphetamines elevate extracellular dopamine, but the underlying mechanisms remain uncertain. Here we show in rodents that acute pharmacological inhibition of the vesicular monoamine transporter (VMAT) blocks amphetamine-induced ... -
Metal quinolinolate-fullerene(s) donor-acceptor complexes: evidence for organic LED molecules acting as electron donors in photoinduced electron-transfer reactions
(American Chemical Society, 2008-12-17)Tris(quinolinolate)aluminum(III) (AlQ3) is the most widely used molecule in organic light-emitting devices. There exists a strong demand for understanding the photochemical and photophysical events originating from this ... -
Method development for separation and analysis of tire and road wear particles from roadside soil samples
(American Chemical Society, 2022-09-06)A comprehensive understanding of tire and road wear particles (TRWPs) and their detection and quantification in soils is still challenged by the lack of well-set standardized methods, inherent technological inconsistencies, ... -
Microcapsules through polymer complexation. I: Complex coacervation of polymers containing a high charge density
(Elsevier, 1991-05-01)Acidic and basic methacrylate co- and ter-polymers based on (respectively) methacrylic acid (MAA) and dimethylaminoethyl methacrylate (DMAEMA) were prepared by solution free radical polymerization and structurally characterized ... -
Microcapsules through polymer complexation. II. By complex coacervation of polymers containing a low charge density
(Elsevier, 1991-07-01)Relationships between ionizable group content, structure and molecular weight, solubility and solution behaviour, and the efficacy of ionic complex formation through complex coacervation, have been established for a range ... -
Microcapsules through polymer complexation. Part 3: encapsulation and culture of human Burkitt lymphoma cells in vitro
(Elsevier, 1995-03-01)Methacrylic acid (MAA) based polyelectrolytes were complexed with protonated or quaternized dimethylaminoethyl methacrylate (DMAEMA) containing polyelectrolytes to form microcapsules in vitro. Anchorage independent human ... -
A microprocessor-controlled photon counter for pulsed optically detected magnetic resonance
(American Institute of Physics, 1979-08-01)In pulsed optically detected magnetic resonance (ODMR) spectroscopy, a lock-in amplifier is used to monitor the signal which is phase-matched to the duty cycle of an applied sequence of pulses. However, since the desired ... -
Microsomal P450-catalyzed N-dealkylation of N,N-dialkylanilines: evidence for a C(alpha)-H abstraction mechanism
(American Chemical Society, 2002-03-06)The early proposal that P450-catalyzed N-dealkylation of N,N-dialkylamines proceeds through a single-electron-transfer (SET) mechanism was later challenged in favor of the C(alpha)-H abstraction mechanism. In the present ... -
Middle-down proteomic analyses with Ion mobility separations of endogenous isomeric proteoforms
(NLM (Medline), 2020-01-14)Biological functions of many proteins are governed by post-translational modifications (PTMs). In particular, the rich PTM complement in histones controls the gene expression and chromatin structure with major health ... -
Mode of substrate interaction and energetics of carbon-oxygen bond formation of the dopamine beta-monooxygenase reaction
(American Chemical Society, 1999-11-09)Previous studies have shown that the dopamine beta-monooxygenase (DbetaM; E.C. 1.14.17.1)/1-(2-aminoethyl)-1,4-cyclohexadiene (CHDEA) reaction partitions between side chain and ring H-abstraction to produce the ... -
Molecular modeling of cetylpyridinium bromide, a cationic surfactant, in solutions and micelle
(American Chemical Society, 2015-11-10)Cationic surfactants are widely used in biological and industrial processes. Notably, surfactants with pyridinium salts, such as cetylpyridinium bromide (CPB), have diverse applications. The cetylpyridium cation has a ... -
Molecular structure characterization by isotopic splitting in nonlinear ion mobility spectra
(American Chemical Society, 2018-01-02)Nearly all compounds comprise numerous isotopologues ensuing from stable natural isotopes for constituent elements. The consequent isotopic envelopes in mass spectra can reveal the ion stoichiometry but not geometry. We ... -
Molecular triads composed of ferrocene, C60, and nitroaromatic entities: electrochemical, computational, and photochemical investigations
(John Wiley and Sons, 2002-12-27)Synthesis and physicochemical characterization of a series of molecular triads composed of ferrocene, C(60), and nitroaromatic entities are reported. Electrochemical studies revealed multiple redox processes involving all ... -
Monitoring anthrax toxin receptor dissociation from the protective antigen by NMR
(John Wiley and Sons, 2009-01-01)The binding of the Bacillus anthracis protective antigen (PA) to the host cell receptor is the first step toward the formation of the anthrax toxin, a tripartite set of proteins that include the enzymatic moieties edema ... -
Mono- and di-nuclear nickel(II) complexes with mixed N/S-donor ligands: Syntheses, structures and physical properties
(Elsevier, 2012-05-03)Two new Ni(II) complexes are reported with tridentate thiosemicarbazone ligands derived from Schiff-base condensation with phenylthiosemicarbazide. Complex 1, a novel dinuclear Ni(II) complex of a SNS ligand synthesized ... -
Multi-stage tandem mass spectrometry of metal cationized leucine enkephalin and leucine enkephalin amide
(John Wiley and Sons, 2002-01-01)We have examined the multi-stage collision induced dissociation (CID) of metal cationized leucine enkephalin, leucine enkephalin amide, and the N-acetylated versions of the peptides using ion trap mass spectrometry. In ... -
Multi-triphenylamine-substituted porphyrin-fullerene conjugates as charge stabilizing "antenna-reaction center" mimics
(American Chemical Society, 2007-09-06)A new concept of charge stabilization via delocalization of the pi-cation radical species over the donor macrocycle substituents in a relatively simple donor-acceptor bearing multimodular conjugates is reported. The newly ... -
Myopalladin promotes muscle growth through modulation of the serum response factor pathway
(Wiley Blackwell, 2019-10-24)Background: Myopalladin (MYPN) is a striated muscle-specific, immunoglobulin-containing protein located in the Z-line and I-band of the sarcomere as well as the nucleus. Heterozygous MYPN gene mutations are associated with ...