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X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives

Huang, Weijun; Yamamoto, Yasufumi; Li, Yi; Dou, Dengfeng; Alliston, Kevin R.; Hanzlik, Robert P.; Williams, Todd D.; Groutas, William C. (American Chemical Society, 2008-04-10)

The mechanism of action of a general class of mechanism-based inhibitors of serine proteases, including human neutrophil elastase (HNE), has been elucidated by determining the X-ray crystal structure of an enzyme-inhibitor ...