Browsing CHEM Faculty Scholarship by Title
Now showing items 264-283 of 493
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Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses
(United States Patent and Trademark Office, 2016-04-12)Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection ... -
Macrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus, and Coronavirus
(Elsevier, 2013-05-16)The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective ... -
Magnetic topological semimetal phase with electronic correlation enhancement in SmSbTe
(Wiley, 2021-08-24)The ZrSiS family of compounds hosts various exotic quantum phenomena due to the presence of both topological nonsymmorphic Dirac fermions and nodal-line fermions. In this material family, the LnSbTe (Ln = lanthanide) ... -
Maleated soybean oil derivatives as versatile reactive diluents: Synthesis, characterization, and evaluation
(John Wiley and Sons Inc, 2021-11-02)Four maleated soybean oil (SBO) derivatives were synthesized and used as bio-based reactive diluents (RDs) for alkyd coating systems. The RDs were prepared in a two-step fashion: (a) Maleation of SBO with maleic anhydride ... -
Mapping the triplet potential energy surface of 1-methyl-8-nitronaphthalene
(American Chemical Society, 2005-07-22)Spin-unrestricted calculations and time-dependent DFT were used to characterize structure and reactivity of 1-methyl-8-nitronaphthalene (1) in the triplet state. Four hybrid models (B3LYP, PBE0, MPW1K, BHLYP) with significantly ... -
McLafferty-type rearrangement in the collision-induced dissociation of Li+, Na+ and Ag+ cationized esters of N-acetylated peptides
(John Wiley and Sons, 2003-01-01)In this study we investigated the multi-stage collision-induced dissociation (CID) of N-terminally acetylated di-, tri- and tetrapeptides in the form of C-terminal ethyl, n-propyl, isopropyl, n-butyl and tert-butyl esters ... -
Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process
(Elsevier, 2004-09-01)We describe herein the design and in vitro biochemical evaluation of a novel class of mechanism-based inhibitors of human leukocyte elastase (HLE) that inactivate the enzyme via an unprecedented enzyme-induced sulfonamide ... -
Mechanism-based inhibition of human leukocyte elastase and cathepsin G by substituted dihydrouracils
(Elsevier, 1994-11-29)A series of dihydrouracil derivatives has been synthesized and investigated for their in vitro inhibitory activity toward human leukocyte elastase (HLE) and cathepsin G (Cath G). Alkyl [sulfonyl(oxy)] uracils 1-2 were found ... -
Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding
(Elsevier, 2009-05-15)A series of mechanism-based inhibitors designed to interact with the S' subsites of serine proteases was synthesized and their inhibitory activity toward the closely-related serine proteases human neutrophil elastase (HNE) ... -
Mechanism-based inhibitors of serine proteinases based on the Gabriel-Colman rearrangement
(Elsevier, 1993-08-16)Neutrophil-derived mediators such as, for example, the serine proteinase elastase, cathepsin G and proteinase 3, play a critical role in inflammatory lung disease. This report describes the design, synthesis and in vitro ... -
Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain
(Nature Publishing Group, 2016-02-16)Amphetamines elevate extracellular dopamine, but the underlying mechanisms remain uncertain. Here we show in rodents that acute pharmacological inhibition of the vesicular monoamine transporter (VMAT) blocks amphetamine-induced ... -
Metal quinolinolate-fullerene(s) donor-acceptor complexes: evidence for organic LED molecules acting as electron donors in photoinduced electron-transfer reactions
(American Chemical Society, 2008-12-17)Tris(quinolinolate)aluminum(III) (AlQ3) is the most widely used molecule in organic light-emitting devices. There exists a strong demand for understanding the photochemical and photophysical events originating from this ... -
Method development for separation and analysis of tire and road wear particles from roadside soil samples
(American Chemical Society, 2022-09-06)A comprehensive understanding of tire and road wear particles (TRWPs) and their detection and quantification in soils is still challenged by the lack of well-set standardized methods, inherent technological inconsistencies, ... -
Microcapsules through polymer complexation. I: Complex coacervation of polymers containing a high charge density
(Elsevier, 1991-05-01)Acidic and basic methacrylate co- and ter-polymers based on (respectively) methacrylic acid (MAA) and dimethylaminoethyl methacrylate (DMAEMA) were prepared by solution free radical polymerization and structurally characterized ... -
Microcapsules through polymer complexation. II. By complex coacervation of polymers containing a low charge density
(Elsevier, 1991-07-01)Relationships between ionizable group content, structure and molecular weight, solubility and solution behaviour, and the efficacy of ionic complex formation through complex coacervation, have been established for a range ... -
Microcapsules through polymer complexation. Part 3: encapsulation and culture of human Burkitt lymphoma cells in vitro
(Elsevier, 1995-03-01)Methacrylic acid (MAA) based polyelectrolytes were complexed with protonated or quaternized dimethylaminoethyl methacrylate (DMAEMA) containing polyelectrolytes to form microcapsules in vitro. Anchorage independent human ... -
A microprocessor-controlled photon counter for pulsed optically detected magnetic resonance
(American Institute of Physics, 1979-08-01)In pulsed optically detected magnetic resonance (ODMR) spectroscopy, a lock-in amplifier is used to monitor the signal which is phase-matched to the duty cycle of an applied sequence of pulses. However, since the desired ... -
Microsomal P450-catalyzed N-dealkylation of N,N-dialkylanilines: evidence for a C(alpha)-H abstraction mechanism
(American Chemical Society, 2002-03-06)The early proposal that P450-catalyzed N-dealkylation of N,N-dialkylamines proceeds through a single-electron-transfer (SET) mechanism was later challenged in favor of the C(alpha)-H abstraction mechanism. In the present ... -
Middle-down proteomic analyses with Ion mobility separations of endogenous isomeric proteoforms
(NLM (Medline), 2020-01-14)Biological functions of many proteins are governed by post-translational modifications (PTMs). In particular, the rich PTM complement in histones controls the gene expression and chromatin structure with major health ... -
Mode of substrate interaction and energetics of carbon-oxygen bond formation of the dopamine beta-monooxygenase reaction
(American Chemical Society, 1999-11-09)Previous studies have shown that the dopamine beta-monooxygenase (DbetaM; E.C. 1.14.17.1)/1-(2-aminoethyl)-1,4-cyclohexadiene (CHDEA) reaction partitions between side chain and ring H-abstraction to produce the ...