Browsing CHEM Faculty Scholarship by Title
Now showing items 251-270 of 491
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Kinetic evidence for channeling of dopamine between monoamine transporter and membranous dopamine-beta-monooxygenase in chromaffin granule ghosts
(American Society for Biochemistry and Molecular Biology, 2004-04-09)The nature of coupling between the uptake and dopamine-beta-monooxygenase (DbetaM) catalyzed hydroxylation of dopamine (DA) was studied in bovine chromaffin granule ghosts. Initial rate and transient kinetics of DA uptake ... -
LacI-DNA-IPTG Loops: Equilibria among conformations by single-molecule FRET
(American Chemical Society, 2013-02-13)The E. coli Lac repressor (LacI) tetramer binds simultaneously to a promoter-proximal DNA binding site (operator) and an auxiliary operator, resulting in a DNA loop, which increases repression efficiency. Induction of the ... -
Latent isocynate derivatives useful for deactivating enzymes
(United States Patent and Trademark Office, 1990-05-29)Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives ... -
Linear and differential ion mobility separations of middle-down proteoforms
(American Chemical Society, 2018)Comprehensive characterization of proteomes comprising the same proteins with distinct post-translational modifications (PTMs) is a staggering challenge. Many such proteoforms are isomers (localization variants) that require ... -
A linear S-bridged trinuclear cobalt(III) complex with 2-aminobenzenethiol: synthesis, crystal structure, and spectroscopic characterization
(Taylor & Francis, 2013-09-10)Treatment of cobalt(II) perchlorate hexahydrate with 2 M equiv. of 2-aminobenzenethiol (Habt) in acetonitrile afforded a tricationic tricobalt complex, [Co{Co(abt)3}2](ClO4)3·2CH3CN, by aerial oxidation. The molecular ... -
Lipophilic cationic cyanines are potent complex I inhibitors and specific in vitro dopaminergic toxins with mechanistic similarities to both rotenone and MPP+
(American Chemical Society, 2016-08-10)We have recently reported that simple lipophilic cationic cyanines are specific and potent dopaminergic toxins with a mechanism of toxicity similar to that of the Parkinsonian toxin MPP+. In the present study, a group of ... -
Loading and release of doxorubicin with magnetic nanotubes
(John Wiley & Sons, Inc., 2015-03)In this work, we study magnetic nanotubes (MNTs) as drug carriers to control the loading and release of doxorubicin (Dox). The inner surfaces of MNTs where Dox molecules are stored are modified with C18-silane and ... -
Localization of post-translational modifications in peptide mixtures via high-resolution differential ion mobility separations followed by electron transfer dissociation
(Springer International Publishing, 2016-12)Precise localization of post-translational modifications (PTMs) on proteins and peptides is an outstanding challenge in proteomics. While electron transfer dissociation (ETD) has dramatically advanced PTM analyses, mixtures ... -
Long-range stabilization of anthrax protective antigen upon binding to CMG2
(American Chemical Society, 2014-09-30)Protective antigen (PA) mediates entry of edema factor (EF) and lethal factor (LF) into the cytoplasmic space of the cells through the formation of a membrane-spanning pore. To do this, PA must initially bind to a host ... -
Low-field differential ion mobility spectrometry of dipole-aligned macromolecules
(American Chemical Society, 2020-09-04)Ion mobility spectrometry (IMS) with mass spectrometry has grown into a powerful approach to simplify complex mixtures, disentangle isomers, and elucidate their geometries. Two established branches are linear IMS based on ... -
LRP6 holds the key to the entry of anthrax toxin
(Elsevier, 2006-03-24)In this issue of Cell, it is demonstrated that the low-density lipoprotein receptor-related protein 6 (LRP6) promotes endocytosis of the anthrax toxin into cells. LRP6 acts as a coreceptor with either TEM8 or CMG2, the two ... -
Macrocyclic and peptidomimetic compounds as broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, caliciviruses and coronaviruses
(United States Patent and Trademark Office, 2016-04-12)Antiviral protease inhibitors, including macrocylic transition state inhibitors and peptidomimetics are disclosed, along with related antiviral compounds, and methods of using the same to treat or prevent viral infection ... -
Macrocyclic Inhibitors of 3C and 3C-like Proteases of Picornavirus, Norovirus, and Coronavirus
(Elsevier, 2013-05-16)The design, synthesis, and in vitro evaluation of the first macrocyclic inhibitor of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus are reported. The in vitro inhibitory activity (50% effective ... -
Magnetic topological semimetal phase with electronic correlation enhancement in SmSbTe
(Wiley, 2021-08-24)The ZrSiS family of compounds hosts various exotic quantum phenomena due to the presence of both topological nonsymmorphic Dirac fermions and nodal-line fermions. In this material family, the LnSbTe (Ln = lanthanide) ... -
Maleated soybean oil derivatives as versatile reactive diluents: Synthesis, characterization, and evaluation
(John Wiley and Sons Inc, 2021-11-02)Four maleated soybean oil (SBO) derivatives were synthesized and used as bio-based reactive diluents (RDs) for alkyd coating systems. The RDs were prepared in a two-step fashion: (a) Maleation of SBO with maleic anhydride ... -
Mapping the triplet potential energy surface of 1-methyl-8-nitronaphthalene
(American Chemical Society, 2005-07-22)Spin-unrestricted calculations and time-dependent DFT were used to characterize structure and reactivity of 1-methyl-8-nitronaphthalene (1) in the triplet state. Four hybrid models (B3LYP, PBE0, MPW1K, BHLYP) with significantly ... -
McLafferty-type rearrangement in the collision-induced dissociation of Li+, Na+ and Ag+ cationized esters of N-acetylated peptides
(John Wiley and Sons, 2003-01-01)In this study we investigated the multi-stage collision-induced dissociation (CID) of N-terminally acetylated di-, tri- and tetrapeptides in the form of C-terminal ethyl, n-propyl, isopropyl, n-butyl and tert-butyl esters ... -
Mechanism-based inactivation of human leukocyte elastase via an enzyme-induced sulfonamide fragmentation process
(Elsevier, 2004-09-01)We describe herein the design and in vitro biochemical evaluation of a novel class of mechanism-based inhibitors of human leukocyte elastase (HLE) that inactivate the enzyme via an unprecedented enzyme-induced sulfonamide ... -
Mechanism-based inhibition of human leukocyte elastase and cathepsin G by substituted dihydrouracils
(Elsevier, 1994-11-29)A series of dihydrouracil derivatives has been synthesized and investigated for their in vitro inhibitory activity toward human leukocyte elastase (HLE) and cathepsin G (Cath G). Alkyl [sulfonyl(oxy)] uracils 1-2 were found ... -
Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding
(Elsevier, 2009-05-15)A series of mechanism-based inhibitors designed to interact with the S' subsites of serine proteases was synthesized and their inhibitory activity toward the closely-related serine proteases human neutrophil elastase (HNE) ...