Browsing CHEM Faculty Scholarship by Title
Now showing items 193-212 of 491
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High-definition ion mobility/mass spectrometry with structural isotopic shifts for nominally isobaric isotopologues
(American Chemical Society, 2023-05-04)We had reported the isotopic envelopes in differential IMS (FAIMS) separations depending on the ion structure. However, this new approach to distinguish isomers was constrained by the unit-mass resolution commingling all ... -
High-performance liquid chromatographic analysis of DNA composition and DNA modification by chloroacetaldehyde
(Elsevier, 1988-12-23)The separation of common and modified deoxyribonucleosides derived from DNA hydrolyzates was examined under different chromatographic conditions on silica-based octadecyl (C18) columns, involving hydrophobic interactions ... -
High-precision megahertz-to-terahertz dielectric spectroscopy of protein collective motions and hydration dynamics
(American Chemical Society, 2018-06-01)The low-frequency collective vibrational modes in proteins as well as the protein-water interface have been suggested as dominant factors controlling the efficiency of biochemical reactions and biological energy transport. ... -
High-resolution differential ion mobility separations/orbitrap mass spectrometry without buffer gas limitations
(American Chemical Society, 2019-04-29)Strong orthogonality between differential ion mobility spectrometry (FAIMS) and mass spectrometry (MS) makes their hybrid a powerful approach to separate isomers and isobars. Harnessing that power depends on high resolution ... -
High-resolution ion mobility separations of isomeric glycoforms with variations on the peptide and glycan levels
(American Chemical Society, 2020-06-05)Glycosylation is a ubiquitous post-translational modification (PTM) that strongly affects the protein folding and function. Glycosylation patterns are impacted by many diseases, making promising biomarkers. Glycans are ... -
HOMO-LUMO energy gap control in platinum(II) biphenyl complexes containing 2,2 '-bipyridine ligands
(Royal Society of Chemistry, 2015-08)A series of platinum(II) biphenyl 2,2'-bipyridine complexes containing electron-donating and electron-withdrawing moieties on the 4 and 4' positions of the bipyridine ligand exhibit emission from excited states in the 600 ... -
How does solvation layer mobility affect protein structural dynamics?
(Frontiers Media S.A., 2018-07-13)Salvation is critical for protein structural dynamics. Spectroscopic studies have indicated relationships between protein and solvent dynamics, and rates of gas binding to heme proteins in aqueous solution were previously ... -
Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
(Elsevier, 1999-08-02)A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase. -
Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters
(Elsevier, 1992-11-16)A series of peptidyl thiobenzyl esters was used to map the active site of human leukocyte proteinase 3. The steady-state kinetics parameters reveal the following features regarding the substrate specificity of proteinase ... -
Hydantoin derivatives. A new class of inhibitors of human leukocyte elastase
(Informa Healthcare, 1990-01-01)Derivatives of hydantoin have been found to inactivate human leukocyte elastase irreversibly. Chymotrypsin and cathepsin G are also inhibited by these compounds. -
Identification of isomers by multidimensional isotopic shifts in high-field ion mobility spectra
(American Chemical Society, 2018-07-03)Nearly all molecules incorporate elements with stable isotopes. The resulting isotopologue envelopes in mass spectra tell the exact stoichiometry but nothing about the geometry. Chromatography and electrophoresis at high ... -
Immobilization and electrochemical redox behavior of cytochrome c on fullerene film-modified electrodes
(Elsevier, 2005-04-01)Two different fullerene film-modified electrodes were prepared and used for surface immobilization and electrochemical property investigation of horse heart cytochrome c (cyt c). Both a pristine fullerene film and ... -
Improving personalized medicine by examining structure-function patterns in the non-conserved regions of lactate dehydrogenase (LDH)
(Federation of American Societies for Experimental Biology, 2017-04)Personalized medicine relies on our ability to make predictions about disease susceptibility based on differences in protein or gene sequences. Recent research has suggested that the non-conserved regions of proteins, those ... -
In search of a COVID-19 vaccine and therapeutics
(Wichita State University, 2020-05-11)Since the emergence of severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, and the end of March 2020, there have been almost 1,500,000 cases of COVID-19 and more than 90,000 deaths worldwide. There are currently ... -
In silico studies of small molecule interactions with enzymes reveal aspects of catalytic function
(MDPI AG, 2017-07-14)Small molecules, such as solvent, substrate, and cofactor molecules, are key players in enzyme catalysis. Computational methods are powerful tools for exploring the dynamics and thermodynamics of these small molecules as ... -
Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides
(Elsevier, 2008-01-15)The interaction of a series of 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides with neutrophil-derived serine proteases was investigated. The nature of the amino acid component, believed to be oriented toward the ... -
Incorporation of thiolate donation using 2,2'-dithiodibenzaldehyde: complexes of a pentadentate N2S3 ligand with relevance to the active site of Co nitrile hydratase
(Elsevier, 2007-10-01)The use of 2,2'-dithiodibenzaldehyde (DTDB) as a reactant for incorporating thiolate donors into the coordination sphere of a transition metal complex without the need for protecting groups is expanded to include the ... -
Influence of "alternative" C-terminal amino acids on the formation of [b3 + 17 + Cat]+ products from metal cationized synthetic tetrapeptides
(John Wiley and Sons, 2004-05-01)The aim of this study was to investigate the dissociation patterns, and in particular the relative abundance of [b(3) + 17 + Cat](+), for peptides with C-termini designed to allow transfer of the -OH required to generate ... -
Influence of a 4-aminomethylbenzoic acid residue on competitive fragmentation pathways during collision-induced dissociation of metal-cationized peptides
(John Wiley and Sons, 2007-01-01)Formation of [bn+17+cat]+ is a prominent collision-induced dissociation (CID) pathway for Li+- and Na+-cationized peptides. Dissociation of protonated and Ag+-cationized peptides instead favors formation of the rival ... -
Influence of a ring substituent on the tendency to form H(2)O adducts to Ag(+) complexes with phenylalanine analogues in an ion trap mass spectrometer
(John Wiley and Sons, 2002-04-01)In a previous report we showed that certain binary Ag(+)-amino acid complexes formed adduct ions by the attachment of a single water and methanol molecule when stored in an ion trap mass spectrometer: complexes with aliphatic ...