Browsing CHEM Faculty Scholarship by Title
Now showing items 185-204 of 493
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The Gabriel-Colman rearrangement in biological systems: design, synthesis and biological evaluation of phthalimide and saccharin derivatives as potential mechanism-based inhibitors of human leukocyte elastase, cathepsin G and proteinase 3
(Elsevier, 1995-02-01)The results of a structure-activity relationship study focusing on the interaction of a series of phthalimide and saccharin derivatives with leukocyte elastase, cathepsin G and proteinase 3 are described. The phthalimide ... -
Gas phase attachment of water and methanol to Ag(I) complexes with alpha-amino acids in an ion trap mass spectrometer
(John Wiley and Sons, 2001-01-01)Electrospray ionization was used to generate gas phase complexes of Ag+ with selected alpha-amino acids. Following storage (isolation without collisional activation) in an ion trap mass spectrometer, the mass spectra ... -
The gas-phase bis-uranyl nitrate complex [(UO(2))(2)(NO(3))(5)](-): Infrared spectrum and structure
(Elsevier, 2011-12-01)The infrared spectrum of the bis-uranyl nitrate complex [(UO(2))(2)(NO(3))(5)](-) was measured in the gas phase using multiple photon dissociation (IRMPD). Intense absorptions corresponding to the nitrate symmetric and ... -
Gas-phase coordination complexes of (UO22+)-O-VI, (NpO22+)-O-VI, and (PuO22+)-O-VI with dimethylformamide
(Springer, 2011-11)Electrospray ionization of actinyl perchlorate solutions in H2O with 5% by volume of dimethylformamide (DMF) produced the isolatable gas-phase complexes, [An(VI)O(2)(DMF)(3)(H2O)](2+) and [An(VI)O(2)(DMF)(4)](2+), where ... -
Gas-phase investigation of Pd(II)-alanine complexes with small native and derivatized peptides containing histidine
(John Wiley and Sons, 2003-09-01)We report here the generation of gas-phase complexes containing Pd(II), a ligand (deprotonated alanine, A-), and/or N-terminus derivatized peptides containing histidine as one of the amino acids. The species were produced ... -
Gas-phase uranyl-nitrile complex ions
(American Chemical Society, 2006-01-26)Electrospray ionization was used to generate doubly charged complex ions composed of the uranyl ion and nitrile ligands. The complexes, with general formula [UO2(RCN)n]2+, n = 0-5 (where R=CH3-, CH3CH2-, or C6H5-), were ... -
Gene expression-based screen for Parkinson's disease identifies GW8510 as a neuroprotective agent
(American Chemical Society, 2016-07)We carried out a gene expression-based in silico screen in order to identify small molecules with gene-expression profiles that are anticorrelated with a gene-expression profile for Parkinson's disease (PD). We identified ... -
A general progress curve method for the kinetic analysis of suicide enzyme inhibitors
(Elsevier, 1996-02-15)The efficiency of suicide inhibitors is expressed in terms of the kinetic parameters KI and kinact and the partition ratio, which are commonly determined by the well-known dilution assay method. Progress curve analysis ... -
Generation and collision-induced dissociation of ammonium tetrafluoroborate cluster ions
(John Wiley and Sons, 2008-07-01)Singly and doubly charged cluster ions of ammonium tetrafluoroborate (NH4BF4) with general formula [(NH4BF4)nNH4]+ and [(NH4BF4)m(NH4)2]2+, respectively, were generated by electrospray ionization (ESI) and their fragmentation ... -
Generation of gas-phase VO2+, VOOH+, and VO2+-nitrile complex ions by electrospray ionization and collision-induced dissociation
(American Chemical Society, 2006-10-19)Cationic metal species normally function as Lewis acids, accepting electron density from bound electron-donating ligands, but they can be induced to function as electron donors relative to dioxygen by careful control of ... -
High-definition ion mobility/mass spectrometry with structural isotopic shifts for nominally isobaric isotopologues
(American Chemical Society, 2023-05-04)We had reported the isotopic envelopes in differential IMS (FAIMS) separations depending on the ion structure. However, this new approach to distinguish isomers was constrained by the unit-mass resolution commingling all ... -
High-performance liquid chromatographic analysis of DNA composition and DNA modification by chloroacetaldehyde
(Elsevier, 1988-12-23)The separation of common and modified deoxyribonucleosides derived from DNA hydrolyzates was examined under different chromatographic conditions on silica-based octadecyl (C18) columns, involving hydrophobic interactions ... -
High-precision megahertz-to-terahertz dielectric spectroscopy of protein collective motions and hydration dynamics
(American Chemical Society, 2018-06-01)The low-frequency collective vibrational modes in proteins as well as the protein-water interface have been suggested as dominant factors controlling the efficiency of biochemical reactions and biological energy transport. ... -
High-resolution differential ion mobility separations/orbitrap mass spectrometry without buffer gas limitations
(American Chemical Society, 2019-04-29)Strong orthogonality between differential ion mobility spectrometry (FAIMS) and mass spectrometry (MS) makes their hybrid a powerful approach to separate isomers and isobars. Harnessing that power depends on high resolution ... -
High-resolution ion mobility separations of isomeric glycoforms with variations on the peptide and glycan levels
(American Chemical Society, 2020-06-05)Glycosylation is a ubiquitous post-translational modification (PTM) that strongly affects the protein folding and function. Glycosylation patterns are impacted by many diseases, making promising biomarkers. Glycans are ... -
HOMO-LUMO energy gap control in platinum(II) biphenyl complexes containing 2,2 '-bipyridine ligands
(Royal Society of Chemistry, 2015-08)A series of platinum(II) biphenyl 2,2'-bipyridine complexes containing electron-donating and electron-withdrawing moieties on the 4 and 4' positions of the bipyridine ligand exhibit emission from excited states in the 600 ... -
How does solvation layer mobility affect protein structural dynamics?
(Frontiers Media S.A., 2018-07-13)Salvation is critical for protein structural dynamics. Spectroscopic studies have indicated relationships between protein and solvent dynamics, and rates of gas binding to heme proteins in aqueous solution were previously ... -
Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
(Elsevier, 1999-08-02)A series of compounds that utilize the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold was synthesized and shown to be highly effective inhibitors of recombinant human skin chymase. -
Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters
(Elsevier, 1992-11-16)A series of peptidyl thiobenzyl esters was used to map the active site of human leukocyte proteinase 3. The steady-state kinetics parameters reveal the following features regarding the substrate specificity of proteinase ... -
Hydantoin derivatives. A new class of inhibitors of human leukocyte elastase
(Informa Healthcare, 1990-01-01)Derivatives of hydantoin have been found to inactivate human leukocyte elastase irreversibly. Chymotrypsin and cathepsin G are also inhibited by these compounds.