Browsing CHEM Faculty Scholarship by Title
Now showing items 58-77 of 491
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Caenorhabditis elegans model studies show $MPP^+$is a simple member of a large group of related potent dopaminergic toxins
(American Chemical Society, 2021-01-26)Although the causes of Parkinson’s disease (PD) are not fully understood, the consensus is that a combination of genetic and environmental factors plays a major role. The discovery that the synthetic chemical, 1-methyl-4 ... -
Carbon nanomaterials for new generation solar cells
(American Chemical Society, 2018)Recently, we invented various types of 3D carbon nanomaterials via invented reactions. Those novel materials possess high elec. cond. and large accessible surface area, which are required for ideal electrode materials. ... -
Catalysis of protein folding by chaperones in pathogenic bacteria
(2004-12-14)Molecular chaperones are thought to inhibit off-pathway interactions such as aggregation from occurring without influencing the on-pathway formation of native structure. Here, we present a mechanism whereby the family of ... -
Centrosymmetric or Noncentrosymmetric? Transition Metals Talking in $K_2TGe_3S_8(T = Co, Fe)$
(American Chemical Society, 2021-07-01)Two new quaternary sulfides $K_2TGe_3S_8(T = Co, Fe)$ have been synthesized by a high-temperature solid-state routine and flux growth method. The crystal growth process of $K_2TGe_3S_8(T = Co, Fe)$ was elucidated by in ... -
Chapter 19 -- The Mutagenesis Assistant Program
(Springer International Publishing AG, 2014-06-27)Mutagenesis Assistant Program (MAP) is a web-based statistical tool to develop directed evolution strategies by investigating the consequences at the amino acid level of the mutational biases of random mutagenesis methods ... -
Chapter 3 -- Current Status, Gaps, and Weaknesses of the Mechanism of Selective Dopaminergic Toxicity of MPTP/MPP+
(Elsevier, 2017)Among Parkinson's disease (PD) toxin models, MPTP/MPP+ has been the most popular, extensively characterized, and widely used to identify the cellular mechanisms associated with the selective degeneration of dopaminergic ... -
Characteristics of the mitochondrial and cellular uptake of MPP+ , as probed by the fluorescent mimic, 4'I-MPP+
(2018-08-23)The discovery that 1-methyl-4-phenylpyridinium (MPP+ ) selectively destroys dopaminergic neurons and causes Parkinson’s disease (PD) symptoms in mammals has strengthened the environmental hypothesis of PD. The current ... -
Characterization of a series of 3-amino-2-phenylpropene derivatives as novel bovine chromaffin vesicular monoamine transporter inhibitors
(American Chemical Society, 2003-06-19)A series of 3-amino-2-phenylpropene (APP) derivatives have been synthesized and characterized as novel competitive inhibitors, with K(i) values in the microM range, for the bovine chromaffin granule membrane monoamine ... -
Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor
(Elsevier, 2019-10)Feline infectious peritonitis (FIP) is a highly fatal disease caused by a virulent feline coronavirus in domestic and wild cats. We have previously reported the synthesis of potent coronavirus 3C-like protease (3CLpro) ... -
Characterization of complete histone tail proteoforms using differential ion mobility spectrometry
(American Chemical Society, 2017-05-16)Histone proteins are subject to dynamic post-translational modifications (PTMs) that cooperatively modulate the chromatin structure and function. Nearly all functional PTMs are found on the N-terminal histone domains (tails) ... -
Characterizing dynamical differences between TEM-1 and TEM-52 beta-lactamases
(Cell Press, 2019-02-15)Beta-lactamase, produced in bacteria, defends against beta-lactam antibiotics such as penicillin and cephalosporins by hydrolyzing the beta-lactam ring. This is a primary cause of antibiotic resistance to beta-lactam ... -
Characterizing the intramolecular H-bond and secondary structure in methylated GlyGlyH+ with H2 predissociation spectroscopy
(Springer, 2011-11)We report vibrational predissociation spectra of the four protonated dipeptides derived from glycine and sarcosine, GlyGlyH(+)center dot(H-2)(1,2), GlySarH(+)center dot(D-2)(2), SarGlyH(+)center dot(H-2)(2), and SarSarH(+)center ... -
Charge stabilization in a closely spaced ferrocene-boron dipyrrin-fullerene triad
(Royal Society of Chemistry, 2010-05-21)New molecular triads composed of closely spaced ferrocene-boron dipyrrin-fullerene, 1 and triphenylamine-boron dipyrrin-fullerene, 2 are synthesized, and photoinduced electron transfer leading to charge stabilization is ... -
A charge-stabilizing, multimodular, ferrocene-bis(triphenylamine)-zinc-porphyrin-fullerene polyad
(WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2013-07-15)A novel multimodular donor-acceptor polyad featuring zinc porphyrin, fullerene, ferrocene, and triphenylamine entities was designed, synthesized, and studied as a charge-stabilizing, photosynthetic-antenna/reaction-center ... -
Chiral multisubstrate inhibitors of dopamine beta-monooxygenase: evidence for dual modes of interaction
(American Chemical Society, 1997-06-10)The electronic and steric constraints of the dopamine beta-monooxygenase (DbetaM; E.C. 1.14.17.1) active site were studied using a series of chiral bisubstrate inhibitors. The (R) and (S) enantiomers of 5-phenyl-2-thiooxazolidone ... -
Cluster ions derived from sodium and potassium tetrafluoroborate and their collision induced dissociation in an ion trap mass spectrometer
(John Wiley and Sons, 2002-01-01)Electrospray ionization was used to produce distributions of gas-phase cluster ions from solutions of sodium and potassium tetrafluoroborate. The majority of the cluster species followed the trend (MBF(4))(n)M(+), where ... -
Collision-induced dissociation of protonated tetrapeptides containing beta-alanine, gamma-aminobutyric acid, epsilon-aminocaproic acid or 4-aminomethylbenzoic acid residues
(John Wiley and Sons, 2006-01-01)The influence of the presence and position of a single beta-alanine, gamma-aminobutyric acid, epsilon-aminocaproic acid or 4-aminomethylbenzoic acid residue on the tendency to form b(n)+ -and y(n)+ -type product ions was ... -
Comparison of amorphous iridium water-oxidation electrocatalysts prepared from soluble precursors
(American Chemical Society, 2012-07-16)Electrodeposition of iridium oxide layers from soluble precursors provides a route to active thin-layer electrocatalysts for use on water-oxidizing anodes. Certain organometallic half-sandwich aqua complexes of iridium ... -
Comparison of physical and photophysical properties of monometallic and bimetallic ruthenium(II) complexes containing structurally altered diimine ligands
(American Chemical Society, 1996-11-06)The physical and photophysical properties of a series of monometallic, [Ru(bpy)(2)(dmb)](2+), [Ru(bpy)(2)(BPY)](2+), [Ru(bpy)(Obpy)](2+) and [Ru(bpy)(2)(Obpy)](2+), and bimetallic, [{Ru(bpy)(2)}(2)(BPY)](4+) and ... -
Comparison of solid-state and solution photophysical properties of a platinum(II) biphenyl dicarbonyl complex: a multiple-state emission study
(American Chemical Society, 1998-03-23)Pt(bph)(CO)(2), where bph is the biphenyl dianion, displays multiple emission by altering the temperature, solvent, or its state. Emission spectra and emission quantum yields are concentration and excitation wavelength ...