Browsing BIO Theses by Title
Now showing items 40-59 of 98
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Feasibility of IL21-immunotherapy for microRNA-21 associated osteosarcoma
(Wichita State University, 2018-07)Osteosarcoma has been known as a type of aggressive bone cancer that is characterized by a high inclination for pulmonary metastasis. Despite the current therapeutic regimes including surgical excision of primary tumor, ... -
Follicle-stimulating hormone glycoform interactions with the FSH receptor
(Wichita State University, 2015-07)Follicle-stimulating hormone (FSH) is a gonadotropic hormone produced by the ante-rior pituitary, which plays a major role in follicular development leading up to ovulation and spermatogenesis. FSH possesses two dissimilar ... -
Follicle-stimulating hormone macroheterogeneity and its effect on receptor conformation
(Wichita State University, 2022-07)Follicle-stimulating hormone (FSH) is a glycoprotein hormone that plays a significant role in gonadal development and fertility. FSH is a heterodimeric glycoprotein composed of a common $\beta$-subunit non-covalently ... -
Follicle-stimulating hormone-receptor expression in the aging human ovary
(Wichita State University, 2008-12)The follicles in a human ovary gradually decline in number during infancy, adolescence and the reproductive years. However, during the perimenopausal period there is a more rapid decline in follicles. Older women have fewer ... -
GCNF as a growth regulator in normal and neoplastic cells
(2007-05)Germ cell nuclear factor (GCNF/NCNF/RTR, NR6A1) is an orphan member of the nuclear receptor super family that exhibits repressive transcriptional activity and is expressed in the embryonic stem cells, embryonic carcinoma ... -
Habitat associations of carrion beetle (coleoptera: silphidae) communities found on small mammal carrion in the Kansas Flint Hills
(Wichita State University, 2017-12)Necrophagous insects play an important role in decomposition and nutrient recycling of decomposing animals. Ecological studies of carrion-associated beetles enhance forensic investigations by providing information about ... -
Heads or tails: an analysis of dung beetle (Coleoptera: Scarabaeidae: Scarabaeinae & Aphodiinae) attraction to small mammal carrion
(Wichita State University, 2018-05)Necrophilous insects occupy a biologically interesting ecological niche because carrion is a highly desirable but ephemeral food source. Insects that feed on carrion are widely studied in forensic and entomological ... -
Human follicle-stimulating hormone glycoform abundance during the normal menstrual cycle in women
(Wichita State University, 2009-05)Human FSH exists as two major glycoforms, tetra-glycosylated and di-glycosylated hFSH. Tetra-glycosylated FSH possesses both α and β subunit carbohydrates while di-glycosylated hFSH possesses only α subunit carbohydrates. ... -
Hydrogel mediated neural cell migration for neural repair
(Wichita State University, 2016-05)Astrocytes play a critical role in supporting the normal physiological function of neurons in the central nervous system (CNS). Astrocyte transplantation can potentially promote axonal regeneration and functional recovery ... -
Indirect, plant mediated interactions of meristem miners on flower head feeders, a case for non-independence?
(Wichita State University, 2010-05)A long standing, dominant paradigm in the biological control of weeds is the independence of insect herbivore guilds' effects on their host plant. Recent work has shown stronger interactions among insect herbivore guilds ... -
Insights into the introduction and distribution of invasive Japanese Climbing Fern (Lygodium japonicum) through whole chloroplast sequencing
(Wichita State University, 2022-05)Japanese Climbing Fern (Lygodium japonicum) is a vine native to the open forests of eastern Asia that has become an invasive species in the United States. Herbarium records suggest Florida or North Carolina are the initial ... -
Invasive success of Lespedeza cuneata: allelopathy and competition
(Wichita State University, 2011-12)Lespedeza cuneata is an Asian legume introduced to the U.S. in the 1930s as erosion control and forage, but it can also have strong negative effects on native species and in some cases form dense monocultures. One proposed ... -
Investigating the genetic variations among Medicago truncatula ecotypes in response to pathogenic fungus Macrophomina phaseolina
(Wichita State University, 2012-07)Macrophomina phaseolina, an internationally distributed fungal pathogen, causes a disease known as “charcoal rot” (also known as dry-weather wilt and summer wilt) that clogs vascular tissue and produces yellow, wilted ... -
Mechanism of ovarian disruption by neonatal DES exposure: A further investigation into ovarian function in the hamster cheek pouch
(Wichita State University, 2007-07)Treatment of hamsters on the day of birth with the synthetic estrogen and prototypical endocrine disruptor, diethylstilbestrol (DES), induces severe anomalies throughout the female reproductive tract. The disruption ... -
Migration and bioscaffold interaction of induced pluripotent stem cell-derived human neural stem cells for neural regeneration
(Wichita State University, 2019-07)Spinal cord injuries (SCIs) are extremely debilitating conditions without an effective treatment. Several treatment plans are suggested that focus on replacement stem cells, implantable bioscaffolds, or a combination of ... -
Migration of dental pulp stem cells-derived chondrogenic cells in collagen hydrogels
(Wichita State University, 2017-12)The rapidly progressing field of regenerative medicine draws attention to various sources of adult stem cells that can be differentiated into many cellular lineages and tissues. Human dental pulp stem cells (DPSCs) are ... -
Molecular and phenetic characterization of the bacterial assemblage of Basque Lake, BC, an environment with high concentrations of magnesium sulphate, and its relevance to mars
(Wichita State University, 2017-05)Halotolerant bacteria favor environments containing high concentrations of salts. While there are a multitude of hypersaline environments containing various salts on Earth, those heavily dominated with sodium chloride ... -
Molecular interactions between the pathogenic fungus Macrophomina phaseolina and its plant host Medicago truncatula
(Wichita State University, 2010-08)Macrophomina phaseolina is a necrotrophic soil-borne fungal pathogen that causes a disease commonly known as charcoal rot. This fungus has the potential to infect over 500 different plant species worldwide including many ... -
Navigating nuance in native bee responses to grassland restoration management: A multi-ecoregional approach in the Great Plains
(Wichita State University, 2019-12)Habitat fragmentation due to agricultural intensification leads to losses of biodiversity and ecosystem services such as pollination. Wild bee declines pose a serious threat to pollination stability and are expected to ... -
Paracotalpa ursina species complex revealed: the true biodiversity of the California bear scarabs (Coleoptera: Scarabaeidae)
(Wichita State University, 2014-05)The complex geology of southern California is an important mechanism that drives lineage isolation and promotes high levels of inter- and intraspecific variation. This, in combination with anthropogenic habitat fragmentation, ...