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dc.contributor.advisorMcDonald, J. Daviden_US
dc.contributor.authorGowda, Supriya Srinivasa
dc.date.accessioned2006-12-26T17:04:57Z
dc.date.available2006-12-26T17:04:57Z
dc.date.issued2006-05
dc.identifier.othert06074
dc.identifier.urihttp://hdl.handle.net/10057/387
dc.descriptionThesis (M.S.)--Wichita State University, Dept. of Biological Sciences.en
dc.description"May 2006."en
dc.descriptionIncludes bibliographic references (leaves 36-40)en
dc.description.abstractWomen with untreated phenylketonuria (PKU), tend to give birth to infants with multiple congenital anomalies, as elevated maternal phenylalanine (Phe) level is teratogenic. The best outcomes occur when strict control of maternal Phe levels is achieved before conception and maintained throughout pregnancy. Such diets are not highly palatable and therefore there is often loss of dietary compliance. An alternative to low Phe diet would be a more normal diet that is altered so that the Phe content is less problematic. Hence, there is an interest in the use of large neutral amino acids (LNAA), which compete with Phe for membrane transport sites in the intestines and the placental barrier and thus alleviate the problems associated with PKU. In our research we used a PKU mouse model to examine the effect of LNAA supplementation on the maternal and fetal blood Phe levels. 3 different doses of LNAA supplementation were given to different animal groups to observe its effect on the blood Phe levels. Results showed that 16.7% and 33.4% LNAA supplementation caused significant decrease in the blood Phe levels over a period of time, but was associated with adverse effects.en
dc.format.extentx, 40 leaves : ill., digital, PDF file.
dc.format.extent458839 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen
dc.publisherWichita State Universityen
dc.rightsAccess restricted to WSU students, faculty and staffen
dc.rightsCopyright Supriya Srinivasa Gowda, 2006. All rights reserved.en
dc.subject.lcshElectronic dissertationsen
dc.titleThe effect of large neutral amino acids on maternal phenylketonuria offspringen
dc.typeThesisen
dc.identifier.oclc75621472


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