Nanomonitors: a miniature electronic biosensor for early disease diagnosis -- restricted access to full text
Brandigampala, Savindra Madhavi
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Brandigampala, Savindra, Feikert, Paige & Vattipalli, Krishna (2011). Nanomonitors: A Miniature Electronic Biosensor for Early Disease Diagnosis. -- In Proceedings: 7th Annual Symposium: Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p. 56
The primary purpose of this research is to develop an inexpensive and user friendly "point- of- care" (POC) device also known as Nanomonitor, for early disease diagnosis. Proteomics research has elucidated many new proteins as biomarkers that have the potential to greatly improve disease diagnosis. Our clinical application for this technology is the identification of the cardiovascular diseases which lead to deaths worldwide. Protein biomarker for this condition is C-Reactive Protein (CRP). We have utilized nanoporous alumina membranes to generate high surface area to volume structures for trapping protein biomolecules in Nanomonitor. We employ the protein specific capacitance measurement method as the basis for protein biomarker detection. Furthermore, the device performance parameters have been validated against the clinical gold standard: ELISA. The research objective is to measure the performance parameters (limit of detection, specificity, dynamic range and detection speed) of the Nanomonitor devices for protein biomarker based disease detection, with accuracy greater than 95%.
Paper presented to the 7th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Marcus Welcome Center, Wichita State University, May 4, 2011.
Research completed at the Department of Electrical Engineering and Computer Science Bio-Engineering Program