Comparative binding studies with a tetraurea picket porphyrin receptor using ¹H NMR and isothermal titration calorimetry
Aw, Hong Wai
AdvisorBurns, Dennis H.
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Aw, Hong Wai (2010). Comparative binding studies with a tetraurea picket porphyrin receptor using ¹H NMR and isothermal titration calorimetry. -- In Proceedings: 6th Annual Symposium: Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p. 71-72
The (α, α, α, α)-5,10,15,20-tetrakis(2-(4-fluorophenylurea)phenyl)porphyrin binds strongly (K(M⁻¹)>10⁴) to chloride anion, and close to 2-3 orders of magnitude less to acetate anion, in DMSO-d₆ as revealed by ¹H NMR titration studies. However, acetate anion showed stronger binding than chloride anion when ITC analyses were done. Thus, the binding studies' results vary with the use of instrumental method. Other significant differences and similarities observed in the behavior of anion binding with the porphyrin receptor when using the two probes will also be addressed in this report.
Paper presented to the 6th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Hughes Metropolitan Complex, Wichita State University, April 23, 2010.
Research completed at the Department of Chemistry, College of Liberal Arts and Sciences