The preparation of charged anion receptors to bind anionic components of bacterial membranes
Koralegedara, Manjula B.
AdvisorBurns, Dennis H.
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Koralegedara, Manjula B. (2010). The preparation of charged anion receptors to bind anionic components of bacterial membranes. -- In Proceedings: 6th Annual Symposium: Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p. 39-40
A receptor able to selectively bind a phosphatidylglycerol (PPG) head group is an attractive synthetic target as a modular component of an antimicrobial therapeutic. The major challenge to the preparation of such receptors, able to exclusively recognize this bacterial membrane component, is to create a binding motif that will complex a phosphorus anion, along with hydroxyl functionality, strongly and selectively in an aqueous environment. Herein we report the synthesis and binding studies of a family of charged hydrogen bonding receptors, with phosphate anion and with PPG anion monitored with proton NMR spectroscopy and Isothermal Calorimetry (ITC) to reveal the best fit with the anionic phosphate head group of the PPG.
Paper presented to the 6th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Hughes Metropolitan Complex, Wichita State University, April 23, 2010.
Research completed at the Department of Chemistry, College of Liberal Arts and Sciences