McLafferty rearrangement of peptides and substituent effects on peptide fragmentation: Theoretical and experimental investigation

Abstract

The research presented here details two studies that utilized theoretical analysis and experimentation to further the understading of peptide fragmentation. The first study was the McLafferty rearrangement, which involves transfer of a У-position hydrogen atom to a carbonyl oxygen atom through a cyclic intermediate, followed by the elimination of an alkene. The second study examined substituent effects on benzene ring terminated peptides.