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dc.contributor.authorWang, Jia Wen
dc.contributor.authorAbijoye, Emmanuel
dc.contributor.authorWu, Haifan
dc.identifier.citationWang, Jia Wen, Abijoye, Emmanuel and Wu, Haifan. War on cancer: Development of the covalent inhibitor on KRASG12D. -- Fyre in STEM Showcase, 2023.
dc.descriptionPoster and abstract presented at the FYRE in STEM Showcase, 2023.
dc.descriptionResearch project completed at the Department of Chemistry and Biochemistry.
dc.description.abstractMutations in the KRAS protein, such as G12C and G12D have been linked to many types of cancers including lung, colorectal, and pancreatic. Small molecules specifically targeting KRASG12C have been found to effectively bind to this protein to disable the protein and cease uncontrolled cell growth. Using this small molecule has led to successful cancer treatments with this cysteine (G12C) mutation. However, no such small molecule has been synthesized that can covalently bind to the aspartate (G12D) mutation to disable this protein, even though KRASG12D is the more common form of the KRAS mutations. Our overall goal is to synthesize a small molecule to target the Asp12 on the KRASG12D mutation using 2H-azirine. We have successfully purified three constructs of the KRAS protein: KRAS wild type, KRASG12C, and KRASG12D as well as incorporated GDP in each construct. GDP-bound KRAS is inactive. Small molecules targeting and maintaining this KRAS state can reduce cell proliferation. We are in the process of synthesizing the inhibitor to covalently label Asp12. If successful, this small molecule inhibitor would create opportunities for treatments of KRASG12D mutations.
dc.publisherWichita State University
dc.relation.ispartofseriesFYRE in STEM 2023
dc.subjectCancer treatment
dc.titleWar on cancer: Development of the covalent inhibitor on KRASG12D
dc.rights.holderCopyright by authors, 2023

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  • FYRE in STEM 2023
    Publication of the First Year Research Experience in Science, Technology, Engineering, and Mathematics program

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