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dc.contributor.advisorGroutas, William C.en_US
dc.contributor.authorHe, Guijiaen_US
dc.date.accessioned2010-09-01T15:12:06Z
dc.date.available2010-09-01T15:12:06Z
dc.date.issued2009-12en_US
dc.identifier.othert09065en_US
dc.identifier.urihttp://hdl.handle.net/10057/2511
dc.descriptionThesis (M.S.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistryen_US
dc.description.abstractHuman neutrophil elastase (HNE) and proteinase 3 (PR3) are serine proteases which play a crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD), a multifactorial disorder associated with an imbalance between the levels of COPD-relevant proteases and their physiological protein inhibitors. The N-amino-4-imidazolidinone scaffold was used in the design and synthesis of potential inhibitors of HNE and PR3. The results show that this is a promising avenue of investigation for the development of reversible competitive inhibitors with good selectivity toward HNE and PR3. Molecular docking simulations are supportive of the validity of this approach.en_US
dc.format.extentxii, 48 p.en_US
dc.format.extent1007947 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherWichita State Universityen_US
dc.titlePotential inhibitors of COPD-relevant serine proteases based on the N-amino-4-imidazolidinone scaffolden_US
dc.typeThesisen_US


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