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dc.contributor.authorPrince, Alisha
dc.contributor.authorRoy, Soumya
dc.contributor.authorMcDonald, David
dc.date.accessioned2023-01-09T16:59:39Z
dc.date.available2023-01-09T16:59:39Z
dc.date.issued2022-04-21
dc.identifier.citationPrince, A., Roy, S., & McDonald, D. (2022). Exploration of the Antimicrobial Synergy between Selected Natural Substances on Streptococcus mutans to Identify Candidates for the Control of Dental Caries. Microbiology Spectrum, 10(3), e02357-02321. https://doi.org/10.1128/spectrum.02357-21
dc.identifier.issn2165-0497
dc.identifier.urihttps://doi.org/10.1128/spectrum.02357-21
dc.identifier.urihttps://soar.wichita.edu/handle/10057/24855
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
dc.description.abstractDental caries is caused by the buildup of acidic end products that result from the metabolism of dental plaque microbes. Natural products that are widely available could be used as an alternative or adjunctive anti-caries therapy. Sometimes, when two products are used together, they yield a more powerful antimicrobial effect than the anticipated additive effect. These synergistic combinations are often better treatment options because individual agents may not have sufficient antimicrobial action to be effective when used alone. Cranberries contain phenolic compounds like proanthocyanidins (PAC) that disrupt biofilm formation. Manuka honey has high concentrations of the agent methylglyoxal (MGO), which is cariostatic. Because these agents have varied modes of antimicrobial action, they show potential for possible synergistic effects when paired. Various cranberry extracts were tested pairwise with manuka honey or MGO by well-diffusion assays and 96-well checkerboard assays in the presence of Streptococcus mutans to test for synergy. Synergy was demonstrated in cranberry extracts Type R and RE when paired with manuka honey and MGO. The synergistic combinations found in this research thus can be considered candidates for the formulation of a dentifrice that could be used to inhibit the formation of dental plaque and thereby avoid the development of caries.
dc.description.sponsorshipThis research was in part funded by Ocean Spray Cranberry Inc.
dc.language.isoen_US
dc.publisherAmerican Society for Microbiology
dc.relation.ispartofseriesMicrobiology Spectrum
dc.relation.ispartofseriesVolume 10, No. 3
dc.subjectStreptococcus mutans
dc.subjectCranberry extracts
dc.subjectProanthocyanidins
dc.subjectManuka honey
dc.subjectMethylglyoxal
dc.subjectAntimicrobial combinations
dc.subjectAntimicrobial synergy
dc.titleExploration of the antimicrobial synergy between selected natural substances on Streptococcus mutans to identify candidates for the control of dental caries
dc.typeArticle
dc.rights.holder© 2022 Prince et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.


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