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dc.contributor.advisorBurns, Dennis H.en_US
dc.contributor.authorMeece, Frederick A.en_US
dc.date.accessioned2010-05-03T18:38:51Z
dc.date.available2010-05-03T18:38:51Z
dc.date.issued2009-05en_US
dc.identifier.otherd09011en_US
dc.identifier.urihttp://hdl.handle.net/10057/2382
dc.descriptionThesis (Ph.d.)--Wichita State University, College of Liberal Arts and Sciences, Dept. of Chemistryen_US
dc.description.abstractReceptors specific for inorganic anions have been described for several decades. Several of these anions, i.e. chloride, phosphate, and acetate are essential in biology. A novel neutral anion receptor specific for the phosphate containing head group of bacterial membrane fatty acids was conceptualized as part of a possible broad spectrum antibiotic. The receptor and several related derivatives were synthesized over fourteen steps. The most important step which involved placing ureidomethylene groups to a bis‐phenolic scaffold was developed as a novel method. The method was probed for scope and utility with a variety of aromatic nucleophiles. The aforementioned anion receptors were tested for binding capabilities against several inorganic anions, and against a synthetic tetrabutylammonium salt of a phospholipid. Several of the derivatives were also tested for antibiotic activity against several species of gram negative bacteria. Finally, the receptors were used to bind chloride anion in solvents containing a variable amount of water to determine if the presence of water would result in stronger anion binding.en_US
dc.format.extentxxi, 217 p.en_US
dc.format.extent10094872 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherWichita State Universityen_US
dc.subject.lcshElectronic dissertationsen
dc.titleStudies towards small-molecule-receptors selective for phospholipid anionic head groups in bacterial membranesen_US
dc.typeDissertationen_US


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