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dc.contributor.authorIjaola, Ahmed O.
dc.contributor.authorAkamo, Damilola O.
dc.contributor.authorDamiri, Fouad
dc.contributor.authorAkisin, Cletus John
dc.contributor.authorBamidele, Emmanuel Anuoluwa
dc.contributor.authorAjiboye, Emmanuel Gboyega
dc.contributor.authorBerrada, Mohammed
dc.contributor.authorOnyenokwe, Victor Onyebuchukwu
dc.contributor.authorYang, Shang-You
dc.contributor.authorAsmatulu, Eylem
dc.identifier.citationAhmed Olanrewaju Ijaola, Damilola O. Akamo, Fouad Damiri, Cletus John Akisin, Emmanuel Anuoluwa Bamidele, Emmanuel Gboyega Ajiboye, Mohammed Berrada, Victor Onyebuchukwu Onyenokwe, Shang-You Yang & Eylem Asmatulu (2022) Polymeric biomaterials for wound healing applications: a comprehensive review, Journal of Biomaterials Science, Polymer Edition, DOI: 10.1080/09205063.2022.2088528
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dc.description.abstractChronic wounds have been a global health threat over the past few decades, requiring urgent medical and research attention. The factors delaying the wound-healing process include obesity, stress, microbial infection, aging, edema, inadequate nutrition, poor oxygenation, diabetes, and implant complications. Biomaterials are being developed and fabricated to accelerate the healing of chronic wounds, including hydrogels, nanofibrous, composite, foam, spongy, bilayered, and trilayered scaffolds. Some recent advances in biomaterials development for healing both chronic and acute wounds are extensively compiled here. In addition, various properties of biomaterials for wound-healing applications and how they affect their performance are reviewed. Based on the recent literature, trilayered constructs appear to be a convincing candidate for the healing of chronic wounds and complete skin regeneration because they mimic the full thickness of skin: epidermis, dermis, and the hypodermis. This type of scaffold provides a dense superficial layer, a bioactive middle layer, and a porous lower layer to aid the wound-healing process. The hydrophilicity of scaffolds aids cell attachment, cell proliferation, and protein adhesion. Other scaffold characteristics such as porosity, biodegradability, mechanical properties, and gas permeability help with cell accommodation, proliferation, migration, differentiation, and the release of bioactive factors.
dc.description.sponsorshipThe authors would like to thank Wichita State University for funding this research via the MURPA (Multidisciplinary Research Project Award) grant.
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofseriesJournal of Biomaterials Science, Polymer Edition
dc.subjectPolymeric biomaterials
dc.subjectWound healing
dc.subjectWound physiology
dc.subjectTissue engineering
dc.titlePolymeric biomaterials for wound healing applications: a comprehensive review
dc.rights.holder© 2022 Informa UK Limited

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