DNA methylation and its role in a form of hormone-dependent cancer
Issue Date
Embargo End Date
Authors
Advisor
Citation
Simpson, Megan and William Hendry (2009). DNA Methylation and its Role in a form of Hormone-Dependent Cancer . In Proceedings: 5th Annual Symposium: Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p. 58-59
Abstract
Diethylstilbestrol (DES), a synthetic estrogen, was widely administered to pregnant women between 1947 and 1971 on account of a misconception that it could prevent miscarriages. The offspring of these women were diagnosed with various reproductive tract abnormalities, including cancer. We focused this study on DES-induced abnormalities in the uterus. We screened for altered DNA methylation patterns in uteri from control vs. neonatally DES-treated hamsters using MSRF. Preliminary results show differential DNA methylation patterns in uteri of control vs. DES-treated hamsters. Next we will determine the nucleotide sequence of the differentially methylated genetic elements.
Table of Content
Description
Research completed at the Department of Biological Sciences