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dc.contributor.authorWamocha, Humphrey Lusenakaen_US
dc.contributor.authorMisak, Heath Edwarden_US
dc.contributor.authorAsmatulu, Ramazanen_US
dc.date.accessioned2009-11-19T21:47:30Z
dc.date.available2009-11-19T21:47:30Z
dc.date.issued2009-05-01en_US
dc.identifier.citationWamocha, H.L., Misak, E. H. and Asmatulu, R. (2009). Synthesis and Biological Evaluation of Drug-Carrying Magnetic Nanocomposite Particles for Targeted Drug Delivery . In Proceedings: 5th Annual Symposium: Graduate Research and Scholarly Projects. Wichita, KS: Wichita State University, p. 176-177en_US
dc.identifier.urihttp://hdl.handle.net/10057/2249
dc.descriptionPaper presented to the 5th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Hughes Metropolitan Complex, Wichita State University, May 1, 2009.en_US
dc.descriptionResearch completed at the Department of Mechanical Engineering, College of Engineeringen_US
dc.description.abstractDrug-carrying magnetic nanocomposite spheres were synthesized using Co0.5Zn0.5Fe2O4 nanoparticles and poly (D, L-lactide-co-glycolide)(PLGA) for the purpose of magnetic targeted drug delivery. Magnetic nanoparticles (MNP) (~10 nm) were prepared by a chemical co-precipitation of Sulphate salts in the presence of sodium hydroxide. Oil-in-oil emulsion/solvent evaporation technique was conducted at 7000 rpm and 1.5-2 hrs agitation for the synthesis of nanocomposite spheres. Specifically, PLGA and the cancer drug 5-Fluorouracil were first dissolved in Acetonitrile (oily phase I) and combined with MNP. The drug, MNPs and polymer solution was added drop-wise into viscous paraffin oil combined with Span 80 (oily phase II). 10%, 15% and 20% of MNP in the nanocomposite spheres were evaluated in terms of particle size, morphology and magnetic properties using X-ray and SQUID, Fluid flow and Biological trials were carried out to determine their effectiveness in targeted drug delivery.en_US
dc.format.extent205236 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherWichita State University. Graduate Schoolen_US
dc.relation.ispartofseriesGRASPen_US
dc.relation.ispartofseriesv.5en_US
dc.titleSynthesis and biological evaluation of drug-carrying magnetic nanocomposite particles for targeted drug delivery.en_US
dc.typeConference paperen_US


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