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dc.contributor.authorShakyawar, Sushil K.
dc.contributor.authorPandey, Sanjit
dc.contributor.authorHarvey, David J.
dc.contributor.authorBousfield, George R.
dc.contributor.authorGuda, Chittibabu
dc.date.accessioned2021-06-01T03:09:20Z
dc.date.available2021-06-01T03:09:20Z
dc.date.issued2021
dc.identifier.citationShakyawar, S. K., Pandey, S., Harvey, D. J., Bousfield, G., & Guda, C. (2021). FGDB: Database of follicle stimulating hormone glycans. Computational and Structural Biotechnology Journal, 19, 1635-1640. doi:10.1016/j.csbj.2021.03.009en_US
dc.identifier.issn2001-0370
dc.identifier.urihttps://doi.org/10.1016/j.csbj.2021.03.009
dc.identifier.urihttps://soar.wichita.edu/handle/10057/20062
dc.description© 2021 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license.en_US
dc.description.abstractGlycomics, the study of the entire complement of sugars of an organism has received significant attention in the recent past due to the advances made in high throughput mass spectrometry technologies. These analytical advancements have facilitated the characterization of glycans associated with the follicle-stimulating hormones (FSH), which play a central role in the human reproductive system both in males and females utilizing regulating gonadal (testicular and ovarian) functions. The irregularities in FSH activity are also directly linked with osteoporosis. The glycoanalytical studies have been tremendously helpful in understanding the biological roles of FSH. Subsequently, the increasing number of characterized FSH glycan structures and related glycoform data has thrown a challenge to the glycoinformatics community in terms of data organization, storage and access. Also, a user-friendly platform is needed for providing easy access to the database and performing integrated analysis using a high volume of experimental data to accelerate FSH-focused research. FSH Glycans DataBase (FGDB) serves as a comprehensive and unique repository of structures, features, and related information of glycans associated with FSH. Apart from providing multiple search options, the database also facilitates an integrated user-friendly interface to perform the glycan abundance and comparative analyses using experimental data. The automated integrated pipelines present the possible structures of glycans and variants of FSH based on the input data, and allow the user to perform various analyses. The potential application of FGDB will significantly help both glycoinformaticians as well as wet-lab researchers to stimulate the research in this area.en_US
dc.description.sponsorshipThis work was supported by NIH Grant # 2P01AG029531 to GB(subcontract to CG). The authors would like to thank the Bioinfor-matics and Systems Biology Core (BSBC) facility at UNMC for pro-viding the computational infrastructure and support. BSBC is partlysupported by the Nebraska Research Initiative and NIH awards[5P20GM103427, 5P30CA036727] to CG.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesComputational and Structural Biotechnology Journal;Vol. 19
dc.subjectFollicle stimulating hormonesen_US
dc.subject(FSH)Glycan structuresen_US
dc.subjectGlycoprotein databaseen_US
dc.subjectGlycomicsen_US
dc.subjectGlycan abundance analysisen_US
dc.titleFGDB: Database of follicle stimulating hormone glycansen_US
dc.typeArticleen_US
dc.rights.holder© 2021 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND licenseen_US


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