Development of flexible ion-selective electrodes for saliva sodium detection
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Lim, H. -., Lee, S. M., Mahmood, M., Kwon, S., Kim, Y. -., Lee, Y., & Yeo, W. -. (2021). Development of flexible ion-selective electrodes for saliva sodium detection. Sensors, 21(5), 1-11. doi:10.3390/s21051642
Abstract
Saliva can be used for health monitoring with non-invasive wearable systems. Such devices, including electrochemical sensors, may provide a safe, fast, and cost-efficient way of detecting target ions. Although salivary ions are known to reflect those in blood, no available clinical device can detect essential ions directly from saliva. Here, we introduce an all-solid-state, flexible film sensor that allows highly accurate detection of sodium levels in saliva, comparable to those in blood. The wireless film sensor system can successfully measure sodium ions from a small volume of infants’ saliva (<400 µL), demonstrating its potential as a continuous health monitor. This study includes the structural characterization and error analysis of a carbon/elastomer-based ion-selective electrode and a reference electrode to confirm the signal reliability. The sensor, composed of a pair of the electrodes, shows good sensitivity (58.9 mV/decade) and selectivity (log K = −2.68 for potassium), along with a broad detection range of