A review of inherited cancer susceptibility syndromes
Spencer, Danielle M.
Parker, Ashley N.
Rogers, Corey A.
MetadataShow full item record
Brown, Gina R. MPAS, PA-C; Simon, Madeline MPA, PA-C; Wentling, Chris MPA, PA-C; Spencer, Danielle M. MPA, PA-C; Parker, Ashley N. MPA, PA-C; Rogers, Corey A. MPAS, PA-C A review of inherited cancer susceptibility syndromes, Journal of the American Academy of Physician Assistants: December 2020 - Volume 33 - Issue 12 - p 10-16 doi: 10.1097/01.JAA.0000721648.46099.2c
Inherited cancer syndromes are caused by genetic mutations that place patients at an increased risk for developing cancer. Although most cancers are not caused by genetic inheritance, clinicians must understand these syndromes and be able to recognize their common characteristics. A thorough family history and identification of common patterns as well as specific clinical signs and symptoms can help with early recognition. This article describes symptoms of the more common cancer syndromes, including hereditary breast and ovarian cancer, Li-Fraumeni, Lynch, familial adenomatous polyposis, retinoblastoma, multiple endocrine neoplasia, and von Hippel-Lindau. Important patient education regarding genetic testing also is covered.
Click on the DOI link to access the article (may not be free).