Compounds for inhibiting bacterial growth via phosphatidylglycerol binding
Burns, Dennis H.
English, Douglas S.
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Burns, Dennis H.; English, Douglas S., inventors. Wichita State University, assignee. Compounds for inhibiting bacterial growth via phosphatidylglycerol binding. United States patent U.S. 10,668,048. 2020, June 2.
Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.
WSU inventors: Dennis H. Burns, Dept. of Chemistry, College of Liberal Arts and Sciences, Douglas S. English, Dept. of Chemistry, College of Liberal Arts and Sciences
Application No. 16/048,009 filed July 27, 2018. Patent No: U.S. 10,668,048 granted June 2, 2020