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    Protective antigen complexes with increased stability and uses thereof

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    U.S. 10,188,716 (1.625Mb)
    Date
    2019-01-29
    Author
    Bann, James G.
    Miyagi, Masaru
    Metadata
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    Citation
    Bann, James G.; Miyagi, Masaru, inventors. Wichita State University; Case Western Reserve University, assignees. Protective antigen complexes with increased stability and uses thereof. United States patent U.S. 10,188,716. 2019, Jan. 29.
    Abstract
    Immunogenic compositions against Bacillus anthracis comprising a stabilized protective antigen complex are disclosed. The stabilized complex comprises protective antigen protein and capillary morphogenesis protein-2, with the capillary morphogenesis protein-2 being bound to the protective antigen protein along a binding interface. The stabilized protective antigen complex has increased thermal and structural stability, along with resistance to premature proteolytic degradation. Methods of using the same to induce an immunogenic response in a subject against B. anthracis infection are also disclosed.
    Description
    WSU inventor: James G. Bann, Dept. of Chemistry, College of Liberal Arts and Sciences

    Application No: 15/886,112 filed Feb. 1, 2018. Patent No. 10,188,716 granted Jan. 29, 2019
    URI
    https://patentimages.storage.googleapis.com/fa/c0/cd/5d42596483c287/US10188716.pdf
    http://hdl.handle.net/10057/17159
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