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dc.contributor.authorGong, Xuan
dc.contributor.authorJiang, Jianhao
dc.contributor.authorCeylan, Muhammet
dc.contributor.authorDart, Bradley
dc.contributor.authorAsmatulu, Ramazan
dc.contributor.authorYang, Shang-You
dc.identifier.citationGong, Xuan; Jiang, Jianhao; Ceylan, Muhammet; Dart, Bradley; Asmatulu, Ramazan; Yang, Shang-You. 2019. Il-21 vector-tethering nanofibers for cancer treatment including osteosarcoma. 42nd Society for Biomaterials Annual Meeting and Exposition 2019, vol. 40:pt. 1:pp 573en_US
dc.descriptionClick on the URI link to access the article (may not be free).en_US
dc.description.abstractThe first line of treatment regime for bone cancers including osteosarcoma is surgical removal of the primary tumor, scaffold and/or bone fillers are required to fill the bone void during the surgery. Development and advancement of adjuvant chemotherapy and immunotherapy promotes tumoricidal activity and improves patients’ survival rate. IL-21 is a recently identified cytokine that has strong effects on both CD8+ and CD4+ cells and could be a good candidate for cancer immune therapy. The current study was to develop and characterize an electro-spun PCL nanofiber membrane with IL-21 plasmid vectors that can be used as a wrapping material on the bone tumor removal surgery, and serves as a gene delivery tool to provide persistent IL-21 expression at the site to promote local immunity.en_US
dc.publisherSociety for Biomaterialsen_US
dc.relation.ispartofseries42nd Society for Biomaterials Annual Meeting and Exposition 2019;v.40:pt.1
dc.subjectGene expressionen_US
dc.subjectGene transferen_US
dc.subjectTransplantation (surgical)en_US
dc.titleIl-21 vector-tethering nanofibers for cancer treatment including osteosarcomaen_US
dc.typeConference paperen_US
dc.rights.holder© 2019 Omnipress - All rights reserved.en_US

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