Il-21 vector-tethering nanofibers for cancer treatment including osteosarcoma
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Gong, Xuan; Jiang, Jianhao; Ceylan, Muhammet; Dart, Bradley; Asmatulu, Ramazan; Yang, Shang-You. 2019. Il-21 vector-tethering nanofibers for cancer treatment including osteosarcoma. 42nd Society for Biomaterials Annual Meeting and Exposition 2019, vol. 40:pt. 1:pp 573
The first line of treatment regime for bone cancers including osteosarcoma is surgical removal of the primary tumor, scaffold and/or bone fillers are required to fill the bone void during the surgery. Development and advancement of adjuvant chemotherapy and immunotherapy promotes tumoricidal activity and improves patients’ survival rate. IL-21 is a recently identified cytokine that has strong effects on both CD8+ and CD4+ cells and could be a good candidate for cancer immune therapy. The current study was to develop and characterize an electro-spun PCL nanofiber membrane with IL-21 plasmid vectors that can be used as a wrapping material on the bone tumor removal surgery, and serves as a gene delivery tool to provide persistent IL-21 expression at the site to promote local immunity.
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