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dc.contributor.authorSutton, Mark A.
dc.contributor.authorBurton, Aaron S.
dc.contributor.authorZaikova, Elena
dc.contributor.authorSutton, Ryan E.
dc.contributor.authorBrinckerhoff, William B.
dc.contributor.authorBevilacqua, Julie G.
dc.contributor.authorWeng, Margaret M.
dc.contributor.authorMumma, Michael J.
dc.contributor.authorJohnson, Sarah Stewart
dc.date.accessioned2019-04-21T04:18:55Z
dc.date.available2019-04-21T04:18:55Z
dc.date.issued2019-03-29
dc.identifier.citationSutton, Mark A.; Burton, Aaron S.; Zaikova, Elena; Sutton, Ryan E.; Brinckerhoff, William B.; Bevilacqua, Julie G.; Weng, Margaret M.; Mumma, Michael J.; Johnson, Sarah Stewart. 2019. Radiation tolerance of nanopore sequencing technology for life detection on Mars and Europa. Scientific Reports, vol. 9:article 5370en_US
dc.identifier.issn2045-2322
dc.identifier.otherWOS:000462730200003
dc.identifier.urihttps://doi.org/10.1038/s41598-019-41488-4
dc.identifier.urihttp://hdl.handle.net/10057/16027
dc.descriptionThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_US
dc.description.abstractThe search for life beyond Earth is a key motivator in space exploration. Informational polymers, like DNA and RNA, are key biosignatures for life as we know it. The MinION is a miniature DNA sequencer based on versatile nanopore technology that could be implemented on future planetary missions. A critical unanswered question is whether the MinION and its protein-based nanopores can withstand increased radiation exposure outside Earth's shielding magnetic field. We evaluated the effects of ionizing radiation on the MinION platform - including flow cells, reagents, and hardware - and discovered limited performance loss when exposed to ionizing doses comparable to a mission to Mars. Targets with harsher radiation environments, like Europa, would require improved radiation resistance via additional shielding or design refinements.en_US
dc.description.sponsorshipAstromaterials and Exploration Science Division at the NASA Johnson Space Center. MAS was supported as an extended Fellow of the URAA Program (Undergraduate Research Associates in Astrobiology), funded through award 13-13NAI7-0032 to the Goddard Center for Astrobiology as part of the NASA Astrobiology Institute. This work was partially supported by a Georgetown University Pilot Grant to SSJ.en_US
dc.language.isoen_USen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.ispartofseriesScientific Reports;v.9:article5370
dc.subjectMeteoritesen_US
dc.subjectMoleculesen_US
dc.titleRadiation tolerance of nanopore sequencing technology for life detection on Mars and Europaen_US
dc.typeArticleen_US


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